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Annotation and Curation of Uncharacterized Proteins: Systems Biology Approaches<br></h1></div><span id="ctl00_ctl00_MainContentPlaceHolder_ContentAreaMainContent_ucSpecialTopicDetailList_imgSpan" class="" style="border:0px;font-size:11px;margin:0px;padding:0px;vertical-align:baseline;color:rgb(112,113,115);font-family:'Lucida Grande','Trebuchet MS',Arial,sans-serif;line-height:18px"></span><span style="color:rgb(112,113,115);font-family:'Lucida Grande','Trebuchet MS',Arial,sans-serif;font-size:11px;line-height:18px"></span><div id="ctl00_ctl00_MainContentPlaceHolder_ContentAreaMainContent_ucSpecialTopicDetailList_divHeaderText" class="" style="border:0px;font-size:11px;margin:0px;padding:0px 0px 15px;vertical-align:baseline;width:308px;float:left;height:auto;color:rgb(112,113,115);font-family:'Lucida Grande','Trebuchet MS',Arial,sans-serif;line-height:18px">
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<p class="" style="border:0px;font-size:12px;margin:0px;padding:0px;vertical-align:baseline;line-height:16px;color:rgb(62,61,64)!important"><a href="http://www.frontiersin.org/Community/WhosWhoActivity.aspx?sname=PrashanthSuravajhala&UID=55577" style="border:0px;margin:0px;padding:0px 0px 5px;vertical-align:baseline;outline:0px;color:rgb(62,61,64)!important;text-decoration:none!important">Prashanth Suravajhala</a>, Bioinformatics.org and <span id="ctl00_ctl00_MainContentPlaceHolder_ContentAreaMainContent_ucSpecialTopicDetailList_repSpecialTopicsAuthors_ctl00_lblHostedBy_University" class="" style="border:0px;margin:0px;padding:0px 6px 0px 0px;vertical-align:baseline">Bioclues.org</span> <br>
<a href="http://www.frontiersin.org/Community/WhosWhoActivity.aspx?sname=AlfredoBenso&UID=126471" style="border:0px;margin:0px;padding:0px 0px 5px;vertical-align:baseline;outline:0px;color:rgb(62,61,64)!important;text-decoration:none!important">Alfredo Benso</a>, <span id="ctl00_ctl00_MainContentPlaceHolder_ContentAreaMainContent_ucSpecialTopicDetailList_repSpecialTopicsAuthors_ctl01_lblHostedBy_University" class="" style="border:0px;margin:0px;padding:0px 6px 0px 0px;vertical-align:baseline">Politecnico di Torino, Italy</span> <br>
<a href="http://www.frontiersin.org/Community/WhosWhoActivity.aspx?sname=JayaramanValadi&UID=126476" style="border:0px;margin:0px;padding:0px 0px 5px;vertical-align:baseline;outline:0px;color:rgb(62,61,64)!important;text-decoration:none!important">Jayaraman Valadi</a>, <span id="ctl00_ctl00_MainContentPlaceHolder_ContentAreaMainContent_ucSpecialTopicDetailList_repSpecialTopicsAuthors_ctl02_lblHostedBy_University" class="" style="border:0px;margin:0px;padding:0px 6px 0px 0px;vertical-align:baseline">Shiv Nadar University , India</span> <br>
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</div><p class="" style="border:0px;font-size:16px;margin:0px;padding:0px;vertical-align:baseline;color:rgb(62,61,64);font-family:Georgia,'Times New Roman',Times,serif;line-height:22px">A hypothetical protein (HPs) is a protein whose existence is predicted but whether or not it is expressed remains uncertain. However, many HPs in the recent past have been known to be expressed in vivo. With various methods known to identify components in cell membrane, the functional significance of thousands of proteins, especially those that that have no functional annotations, not expressed, unique or common among genomes, is least understood. Apart from this, many HPs might turn out to be pseudogenes at a later point of time and the use of these proteins remains mis-conducive. To better understand the problem many different areas have been investigated, from methods to screen functional candidates among many hypothetical proteins using feature selection algorithms, to the application of statistical methods to test the efficacy of these proteins annotations in terms of precision and accuracy. With experimental procedures for HP function prediction being low throughput by nature, there is a strong need to precisely know their functions for a better understanding of the underlying biological mechanisms associated with them. We encourage authors interested in protein annotation research to contribute in any of the following areas: <br>
<br>1.    Computational flow for the functional annotation of uncharacterized proteins using motif discovery, sequence and structural similarity, structural homology, hypothome (interactome of hypothetical proteins) or combination of data from highly similar non-interacting proteins (Similactors). <br>
2.      Predictive approaches based on Gene Ontology (GO). <br>3.        Feature selection and machine learning methods. <br>4.   Diseasome approaches.</p><p class="" style="border:0px;font-size:16px;margin:0px;padding:0px;vertical-align:baseline;color:rgb(62,61,64);font-family:Georgia,'Times New Roman',Times,serif;line-height:22px">
<br></p><p class="" style="border:0px;font-size:16px;margin:0px;padding:0px;vertical-align:baseline;color:rgb(62,61,64);font-family:Georgia,'Times New Roman',Times,serif;line-height:22px">More here: <a href="http://www.frontiersin.org/bioinformatics_and_computational_biology/researchtopics/annotation_and_curation_of_unc/2557">http://www.frontiersin.org/bioinformatics_and_computational_biology/researchtopics/annotation_and_curation_of_unc/2557</a> </p>
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<div><span lang="EN-US"><font color="#000099"><b>Prashanth Suravajhala, PhD.<br></b></font></span><p style="margin:0px 0px 0.0001pt"><span style="font-family:arial,helvetica,sans-serif;font-size:x-small">Linkedin: </span><a href="http://dk.linkedin.com/in/prashbio" style="font-family:arial,helvetica,sans-serif;font-size:x-small" target="_blank">http://dk.linkedin.com/in/prashbio </a><br>
</p></div><div><font size="1" face="arial, helvetica, sans-serif"><br></font><font face="georgia, serif"><span style="color:rgb(87,87,86);letter-spacing:0.12800000607967377px;line-height:34px">“Be who you are and say what you feel, because those who mind don’t matter and those who matter don’t mind.” </span><span style="color:rgb(87,87,86);letter-spacing:0.12800000607967377px;line-height:34px">-</span><span style="color:rgb(37,37,37);line-height:22.399999618530273px">Theodor Seuss Geisel</span></font><font face="times new roman, serif"><br>
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