<html><head><meta http-equiv="Content-Type" content="text/html charset=us-ascii"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div><span style="line-height: 19.5px; background-color: rgb(255, 255, 255);">We are seeking to fill a vacant full-time postdoctoral position for three years. The advent of next-generation sequencing technologies has enabled a rapid identification of alterations in cancer genomes, allowing researchers to investigate large-scale genome events such as chromosomal lesions and copy-number variations, as well as small-scale aberrations represented by point mutations, small insertions and deletions. Several recent studies have implicated the packaging and higher-order organization of the nuclear genome as an important part of tumorigenesis. This encompasses both the accessibility of DNA through chromatin architecture and chromatin modifications, as well as the three-dimensional organization of chromosomes within the nucleus.</span><br style="border-color: rgb(130, 175, 201) transparent transparent; line-height: 19.5px; background-color: rgb(255, 255, 255);"><span style="line-height: 19.5px; background-color: rgb(255, 255, 255);"> </span><br style="border-color: rgb(130, 175, 201) transparent transparent; line-height: 19.5px; background-color: rgb(255, 255, 255);"><span style="line-height: 19.5px; background-color: rgb(255, 255, 255);">The successful candidate will work in a team of bioinformaticians to assess the importance of prevailing models of genomic organization to explain mechanistic aspects of somatic mutations and mutation signatures in cancer at different levels of resolution. The project will collaborate with scientists working in close collaboration with The Norwegian Cancer Genomics Consortium (NCGC, <a href="http://cancergenomics.no">cancergenomics.no</a>). The computational group also is developing relevant functionality within a published computational framework termed The Genomic HyperBrowser (</span><span style="line-height: 19px;"><a href="http://hyperbrowser.uio.no">hyperbrowser.uio.no</a>)</span></div><div><span style="line-height: 19px;"><br></span></div><div>Further details can be found here:</div><a href="http://www.finn.no/finn/job/fulltime/object?finnkode=54095708&searchclickthrough=true" style="color: purple; font-family: Calibri, sans-serif; font-size: 15px;"><span lang="NO-BOK">http://www.finn.no/finn/job/fulltime/object?finnkode=54095708&searchclickthrough=true</span></a><br><div><br class="webkit-block-placeholder"></div><div apple-content-edited="true">
<div style="color: rgb(0, 0, 0); letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div>---</div><div>Sigve Nakken, PhD</div><div>Postdoctoral Fellow, Dept. of Tumor Biology</div><div>Institute for Cancer Research</div><div>Oslo University Hospital, Norway</div><div>phone: +4795753022</div><div>email: <a href="mailto:sigven@ifi.uio.no">sigven@ifi.uio.no</a></div><div><br></div></div><br class="Apple-interchange-newline"><br class="Apple-interchange-newline">
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