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<p class="MsoNormal"><b><span lang="EN-GB" style="font-size:14.0pt">Bioinformatics PhD position in prostate cancer microRNA and network analysis, Grenoble, France<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB">Context and Subject:<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:27.0pt"><span lang="EN-GB">Our CEA laboratory is involved in cancer research through the identification of key genes acting in the oncogenic process. To that end our laboratory uses RNAi-based screening
approaches. Briefly, it consists in high throughput and high content analysis, of the phenotypic consequences of gene or microRNA depletion at single cell level. This leads to a list of genes / microRNAs implicated in the phenotype of interest (e.g. cell death
of prostate cancer cells).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:27.0pt"><span lang="EN-US">MicroRNAs are small non-coding RNAs (around 20 bases) which are important gene regulators in cells (human, animals, plants, etc.). Discovered in the 90s, more than a thousand
human microRNAs are listed; however, their functions remain largely unknown. Our laboratory has developed a network based approach (biostatistics with R software, graph theory) to investigate microRNAs at a system level (that is considering all microRNAs).
Thanks to this approach, we already identified 3 microRNAs implicated in cancer (Bhajun et al.,
<i>Scientific Reports</i>, 2015).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:27.0pt"><span lang="EN-US">The goal of the proposed PhD thesis is to investigate the role of microRNAs with a system biology approach, in particular in the case of prostate cancer. The PhD student will
integrate our high content screening data, and available data bases (data mining) to further identify microRNA implication in prostate cancer.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:27.0pt"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-indent:27.0pt"><span lang="EN-US">The work, realized in the bioinformatics team of a biological lab (where the data are generated), will be in collaboration with the center of bioinformatics in Mines ParisTech.
It will be codirected by a biologist, a statistician, and co-supervised by a biostatistician.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><u><span lang="EN-GB">Contact:</span></u><span lang="EN-GB">
<a href="mailto:laurent.guyon@cea.fr">laurent.guyon@cea.fr</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-GB">Background of the student</span></u><span lang="EN-GB">:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB">Bioinformatics or Biostatistics / Applied mathematics / Computing, with a strong interest in biology and health application. Knowledge of R would be a plus.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-GB">Application</span></u><span lang="EN-GB"> (as early as possible, ideally before April 5<sup>th</sup> for first round, extended if no outstanding candidate applies)<u><o:p></o:p></u></span></p>
<p class="MsoNormal"><span lang="EN-GB">Applicant must own a Master in bioinformatics, computing, statistics, applied mathematics or related. Applications must be submitted as one pdf file containing all materials. To apply, send an email to Laurent Guyon,
and attach the following materials in English:<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"> - A letter motivating the application (cover letter, max 1 page)<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"> - Curriculum vitae (including at least two references)<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"> - Grade transcripts and BSc/MSc diploma,
<u>including ranks whenever possible</u><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-GB">Web:<o:p></o:p></span></u></p>
<p class="MsoNormal"><span lang="EN-GB"><a href="http://www-dsv.cea.fr/irtsv/bge/biomics">http://www-dsv.cea.fr/irtsv/bge/biomics</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><a href="http://laurent.guyon.phd.free.fr/">http://laurent.guyon.phd.free.fr/</a><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><a href="http://cbio.ensmp.fr/?lang=en&page_name=Overview">http://cbio.ensmp.fr/?lang=en&page_name=Overview</a><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><u><span lang="EN-GB">Keywords<o:p></o:p></span></u></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-GB">microRNAs, system biology, cancer, network biology, data mining<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><u><span lang="EN-GB">References<o:p></o:p></span></u></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:24.1pt;text-indent:-24.1pt">
<span style="font-size:8.0pt;font-family:"Arial","sans-serif""><a href="http://www.nature.com/srep/2015/150212/srep08336/full/srep08336.html">Bhajun, R., Guyon, L., Pitaval, A., Sulpice, E., Combe, S., Obeid, P., … Gidrol, X. (2015). A statistically inferred
microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator.
<i>Scientific reports</i>, <i>5</i>, 8336.</a> <o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:24.1pt;text-indent:-24.1pt">
<span style="font-size:8.0pt;font-family:"Arial","sans-serif""><a href="http://www.ncbi.nlm.nih.gov/pubmed/23029228">Wu, N., Sulpice, E., Obeid, P., Benzina, S., Kermarrec, F., Combe, S., & Gidrol, X. (2012). The miR-17 family links p63 protein to MAPK signaling
to promote the onset of human keratinocyte differentiation. <i>PloS one</i>, <i>
7</i>(9), e45761.</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:8.0pt"><a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020220"><span lang="EN-US">Barrey, E., Saint-Auret, G., Bonnamy, B., Damas, D., Boyer, O., & Gidrol, X. (2011). Pre-microRNA and mature
microRNA in human mitochondria. <i>PloS one</i>, <i>6</i>(5), e20220.</span></a></span><span lang="EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial","sans-serif";color:navy;mso-fareast-language:FR">____________________________</span><span lang="EN-US" style="mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:5.0pt;color:navy;mso-fareast-language:FR"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">Laurent GUYON, PhD – Optics and Biostatistics</span><span lang="EN-GB" style="font-size:12.0pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">CEA Grenoble - Bât 4020 – Travée 116</span><span style="font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">17 rue des Martyrs</span><span style="font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">38054 GRENOBLE Cedex 9</span><span lang="EN-GB" style="font-size:5.0pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:5.0pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">Tél : (+33)4 38 78 31 41</span><span lang="EN-GB" style="font-size:12.0pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">Fax : (+33)4 38 78 59 17</span><span lang="EN-GB" style="font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR">Email :
<a href="mailto:laurent.guyon@cea.fr"><span style="color:blue">laurent.guyon@cea.fr</span></a></span><span lang="EN-GB" style="font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><u><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><a href="http://laurent.guyon.phd.free.fr/"><span style="color:blue">http://laurent.guyon.phd.free.fr/</span></a><o:p></o:p></span></u></p>
<p class="MsoNormal"><u><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS";color:navy;mso-fareast-language:FR"><a href="https://twitter.com/BiomicsLab"><span style="color:blue">https://twitter.com/BiomicsLab</span></a><o:p></o:p></span></u></p>
<p class="MsoNormal"><o:p> </o:p></p>
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