<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
</head>
<body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class="">
<div class="">You will join the recently established group of dr. de Ridder as a PhD student. The de Ridder lab is focussed on creating and applying advanced computational techniques to high-throughput molecular datasets and develops novel data integration
strategies to further disease biology. You will participate in a research project funded by the Gieskes-Strijbis fund. The project is part of a collaboration between the research groups of Dr. W. Kloosterman (Genetics), Prof. H. Clevers, PhD, MD (Hubrecht
Institute) and Prof. dr. E. Witteveen (Medical Oncology). Dr. Kloosterman has a strong background in (cancer) genomics and extensive expertise in the analysis of genome and transcriptome sequencing data. Prof. H. Clevers is director of the Princess Maxima
Center for pediatric oncology and key scientist behind the organoid culture system. Prof. dr. E. Witteveen is an expert on ovarian cancer biology and focuses on testing of novel cancer drugs in clinical trials.</div>
<div class=""><br class="">
</div>
<div class="">The primary focus of the PhD project is the identification and computational characterization of novel mechanisms of drug sensitivity and resistance in ovarian cancer. This will be achieved by establishing and characterizing a “living” organoid
biobank for ovarian cancer using organoid technology, thus capturing to a certain extent the genetic variability of this tumour type. A major part of this project will concern the analysis and interpretation of large-scale genome and transcriptome data and
the selection and molecular characterization of novel genetic variations that are associated with response to chemotherapy or targeted drugs. The latter part involves experimental models, such as mouse, cell lines and organoids, followed by functional assays. </div>
<div class=""><br class="">
</div>
<div class="">If you are (or know someone who is) educated as a bioinformatician or computational biologist with a data analysis mindset, please get in touch! The ideal candidate should have affinity with machine learning, statistics and computational science
in general and demonstrable knowledge of molecular biology and/or cancer biology.</div>
<div class=""><br class="">
</div>
<div class="">For more information: <a href="http://www.werkenbijumcutrecht.nl/vacatures/Paginas/phd-student-group-de-ridder%20(2016-0484).aspx" class="">http://www.werkenbijumcutrecht.nl/vacatures/Paginas/phd-student-group-de-ridder%20(2016-0484).aspx</a></div>
<div class=""><br class="">
</div>
<div class="">Best</div>
<div class=""><br class="">
</div>
<div class="">Jeroen de Ridder</div>
<div class="">Associate Professor - Center for Molecular Medicine - UMC Utrecht</div>
<hr>
<p><font size="-2" face="arial" color="black"><i>
De informatie opgenomen in dit bericht kan vertrouwelijk zijn en is
uitsluitend bestemd voor de geadresseerde. Indien u dit bericht onterecht
ontvangt, wordt u verzocht de inhoud niet te gebruiken en de afzender direct
te informeren door het bericht te retourneren. Het Universitair Medisch
Centrum Utrecht is een publiekrechtelijke rechtspersoon in de zin van de W.H.W.
(Wet Hoger Onderwijs en Wetenschappelijk Onderzoek) en staat geregistreerd bij
de Kamer van Koophandel voor Midden-Nederland onder nr. 30244197.
</i></font></p>
<p><font size="-2" face="arial" color="green"><i>
Denk s.v.p aan het milieu voor u deze e-mail afdrukt.
</i></font></p>
<hr>
<p><font size="-2" face="arial" color="black"><i>
This message may contain confidential information and is intended
exclusively for the addressee. If you receive this message
unintentionally, please do not use the contents but notify the sender
immediately by return e-mail. University Medical Center Utrecht is a legal
person by public law and is registered at the Chamber of Commerce for
Midden-Nederland under no. 30244197.
</i></font></p>
<p><font size="-2" face="arial" color="green"><i>
Please consider the environment before printing this e-mail.
</i></font></p>
</body>
</html>