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<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">mbb-gcb-molneuro <<a href="mailto:MBB-GCB-MOLNEURO@EMAILLIST.KI.SE" target="_blank">MBB-GCB-MOLNEURO@EMAILLIST.KI.SE</a>> on behalf of Goncalo Castelo-Branco <<a href="mailto:goncalo.castelo-branco@KI.SE" target="_blank">goncalo.castelo-branco@KI.SE</a>><br>
<b>Reply to: </b>Goncalo Castelo-Branco <<a href="mailto:goncalo.castelo-branco@ki.se" target="_blank">goncalo.castelo-branco@ki.se</a>><br>
<b>Date: </b>Monday, 27 January 2020 at 17:20<br>
<b>To: </b>"<a href="mailto:MBB-GCB-MOLNEURO@EMAILLIST.KI.SE" target="_blank">MBB-GCB-MOLNEURO@EMAILLIST.KI.SE</a>" <<a href="mailto:MBB-GCB-MOLNEURO@EMAILLIST.KI.SE" target="_blank">MBB-GCB-MOLNEURO@EMAILLIST.KI.SE</a>><br>
<b>Subject: </b>two bioinformatician positions<u></u><u></u></span></p>
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<p class="MsoNormal">Hi group, <u></u><u></u></p>
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<p class="MsoNormal">Would you mind spreading the word in your networks?<u></u><u></u></p>
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<p class="MsoNormal">Thanks!<u></u><u></u></p>
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<p class="MsoNormal">Best,<u></u><u></u></p>
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<p class="MsoNormal">Gonçalo<u></u><u></u></p>
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<p class="MsoNormal"><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.varbi.com%2Fen%2Fwhat%3Ajob%2FjobID%3A313855%2F&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442651839&sdata=SzhMi3MMbSyTsoOc%2Ff3G%2FBp1N6emICv6c%2BjlzzXNr3U%3D&reserved=0" target="_blank"><b><span style="font-size:10.5pt">https://ki.varbi.com/en/what:job/jobID:313855/</span></b></a><u></u><u></u></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">Applications for two bioinformatician positions are welcome at the unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden. One position will be as a core bioinformatician
 at the <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fen%2Fmbb%2Fgoncalo-castelo-branco-group&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442661846&sdata=33Wz5IruwiBvaoEbdS9jPKG5P1bA8g%2FXvOtZPUAXNa8%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">Gonçalo
 Castelo-Branco research group</span></a> and the other position will be for a post-doctoral project, joint with Ana Mendanha Falcao’s group (also at <a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.icvs.uminho.pt%2Fabout-icvs%2Fpeople%2Fanaluisafalcao&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442661846&sdata=1AX0skMV5XX2AWfy%2ByCKBN0YPzN631Sd3H1mc382Y5g%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">University
 of Minho</span></a>, Portugal).<u></u><u></u></span></p>
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<span style="font-size:13.5pt;font-family:"Helvetica Neue";color:#333333;font-weight:normal">Your mission<u></u><u></u></span></h2>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">The successful candidates will be actively working in specific projects with single-cell and bulk transcriptomics and epigenomics, and will be integrated in a multidisciplinary team comprising
 computational, molecular and cellular biologists. The core bioinformatician will also work on web development, data curation, handling of data integration and visualization frameworks, among other tasks.<u></u><u></u></span></p>
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<span style="font-size:13.5pt;font-family:"Helvetica Neue";color:#333333;font-weight:normal">Your profile<u></u><u></u></span></h2>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">We are looking for highly motivated, driven, inquisitive, enthusiastic persons interested in our area of research, and ready to explore new avenues in science. The candidates should have
 a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory.<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">The applicants must have at least a Master in bioinformatics and computational biology (for the core bioinformatician position) or PhD degree (for the post-doctoral bioinformatician position),
 and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. Research experience<b> </b>and expertise in analysis of sequencing data is highly desirable. Wet lab experience is not
 required but it is an advantage for the postdoctoral bioinformatician position.<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">Note: qualification to be employed for the postdoctoral position is a doctoral degree or equivalent scientific competence. Applicants who have not completed a doctorate at the end of
 the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.<u></u><u></u></span></p>
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<span style="font-size:13.5pt;font-family:"Helvetica Neue";color:#333333;font-weight:normal">What do we offer?<u></u><u></u></span></h2>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development
 of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several
 benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">The <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fen%2Fmbb%2Fresearch-division-of-molecular-neurobiology&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442671828&sdata=L1bb9lBLHvxymVYC0ncQ4BOXSauUDWyvd3YUj4Ap3aU%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">Unit
 of Molecular Neurobiology</span></a> has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment.<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">The <a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fen%2Fmbb%2Fgoncalo-castelo-branco-group&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442671828&sdata=2HCUXQ5ALW8A6SkrAthafDMPjTrAhYhc%2B7FbYnAw6Ic%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">Castelo-Branco
 research group</span></a> is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to
 the transition between states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis. Our research group has performed single nuclei/cell
 RNA-Seq and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019). Our findings suggest that oligodendrocyte lineage cells might present other functional
 properties than previously thought.<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">Dr. <a><span style="color:#337ab7;text-decoration:none">Ana Mendanha Falcão</span></a> has
 recently established her research group, which is focusing on the role of the choroid plexus in diseases such as multiple sclerosis. Her team aims to investigate the choroid plexus as a source of biologically active molecules to the central nervous system,
 in order to influence disease dynamics. The choroid plexus will be studied as an alternative target for disease therapies since it can be modulated by peripheral blood and it can substantially alter the brain composition both in terms of biologically active
 molecules and immune cell content.<u></u><u></u></span></p>
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<b><span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">Location: </span></b><span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333">Biomedicum, Solna (Stockholm, Sweden)<u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333"><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fki.se%2Fen%2Fmbb%2Fgoncalo-castelo-branco-group&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442681829&sdata=pl2VorRLoWFDz0Yoc3jYMDEqg1G9xzP6JaDyQrCeHaM%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">https://ki.se/en/mbb/goncalo-castelo-branco-group</span></a><u></u><u></u></span></p>
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<span style="font-size:10.5pt;font-family:"Helvetica Neue";color:#333333"><a href="https://eur01.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.icvs.uminho.pt%2Fabout-icvs%2Fpeople%2Fanaluisafalcao&data=02%7C01%7Cmukund.kabbe%40ki.se%7C08aca3e5fde74e9c6eef08d7a344db98%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C637157388442681829&sdata=MREkExCi1d63L%2BmWj7OGXxr%2BmDIkDA9Gt6I7I6JNfA0%3D&reserved=0" target="_blank"><span style="color:#337ab7;text-decoration:none">http://www.icvs.uminho.pt/about-icvs/people/analuisafalcao</span></a><u></u><u></u></span></p>
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