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We are looking for up to two ambitious bioinformaticians with solid genome-wide bioinformatics/computational biology skills to join our highly accomplished team of immunologists in two European Research Council (ERC)-funded projects (GUT-SEQ and RESIDE). <br class="">
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Bioinformatic position: <a href="https://ki.varbi.com/en/what:job/jobID:403764/" class="">https://ki.varbi.com/en/what:job/jobID:403764/</a>
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<div class="">Postdoc-position: <a href="https://ki.varbi.com/en/what:job/jobID:403852/" class="">https://ki.varbi.com/en/what:job/jobID:403852/</a>
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The Mjösberg and Björkström groups hosting these two positions (one in each group) study development, regulation and function of human innate lymphoid cells (ILCs), including natural killer cells, and how these cells contribute to pathology and normal homeostasis
in organs such as lung, gut, liver and uterus. The studies are translational as they involve advanced basic molecular and cellular immunological investigations of precious human tissue samples to discover novel disease mechanisms and therapy targets. The Mjösberg
group consists of 2 PhD students and 4 postdocs and is internationally recognized as a leader in the ILC-field through several high impact publications in recent years (Nat Immunol 2016, JACI 2019, Cell Res 2021). The Björkström group consists of 3 PhD students
and 4 postdocs and has a strong track-record working on human NK cells in tissues (Sci Immunol 2021, 2020, Sci Trans Med 2021 x2). Both groups work closely together with clinical partners at several Swedish hospitals and laboratory facilities at Science for
Life Laboratories (SciLifeLab), Karolinska Institutet and abroad. The bioinformaticians will work in close collaboration with all members of the respective teams to continue the successful line of investigations utilizing single-cell RNA sequencing (scRNA-seq)
and ATAC-seq to dissect human ILC biology in health and disease.<br class="">
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The bioinformatician will be a part of the Center for Infectious Medicine (CIM), Karolinska Institutet, which is a nationally leading and internationally competitive center for human translational immunology and infectious diseases research. The center consists
of approximately 25 graduate students and 20 postdocs organized around 17 independent research groups. Importantly, the bioinformatician will also be part of a newly formed Center for Bioinformatics and Biostatistics (CBB) at the Karolinska Flemingsberg Campus
which aims at creating a cutting-edge world-leading bioinformatic hub. The CBB facilitates access to the bioinformatics community at the campus and offers mentoring and career-development support.<br class="">
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We are seeking up to two PhDs that will work as an integrated bioinformatician in our teams, being involved in several ongoing projects. We already have large sets of high-throughput sequencing data including scRNA-seq (SMARTseq2 and 10X Genomics) and ATAC-seq
data as well as multicolor flow cytometry data of human ILCs, which will be analyzed in close collaboration with other team members and other bioinformaticians at SciLifeLab and CBB.</div>
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