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<p class="MsoNormal"><span style="font-size:12.0pt">Dear colleagues,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:12.0pt"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-family:"Calibri",sans-serif">In the framework of the <b>small non-coding RNA bioinformatics club</b> (<a href="https://smallrna-bioinformatics.eu/">https://smallrna-bioinformatics.eu/</a>), we are happy to share with you the
<b>seminar of Cynthia Sharma related to mechanisms/functions of small RNAs in bacteria</b>.<o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-family:"Calibri",sans-serif">Caution: the seminar will not be recorded this time.<o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-family:"Calibri",sans-serif">More information here and below (including future seminars):
<a href="https://smallrna-bioinformatics.eu/Pages/Seminars/S22_07.aspx">https://smallrna-bioinformatics.eu/Pages/Seminars/S22_07.aspx</a><o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-family:"Calibri",sans-serif"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline">
<span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535">Start </span><strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Monday July 4th at 4pm</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"> (</span><strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">CET</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535">,
Berlin/Paris)<o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535">(3 pm London/Lisbon, 10am New-York, 7am San Francisco, 5pm Tel Aviv)<o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Link to the Zoom conference:</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"> </span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm"><a href="https://univ-grenoble-alpes-fr.zoom.us/j/93609306988?pwd=SWdvS1RPc0oxbDRRai9GUmpKN0t0dz09" target="_blank"><span style="font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#0E71EB">https://univ-grenoble-alpes-fr.zoom.us/j/93609306988?pwd=SWdvS1RPc0oxbDRRai9GUmpKN0t0dz09</span></a></span><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Link to the YouTube stream:</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm"> </span><span style="color:#353535;border:none windowtext 1.0pt;padding:0cm"><a href="https://www.youtube.com/watch?v=VYIKBJq_coM" target="_blank"><span style="font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#0E71EB">https://www.youtube.com/watch?v=VYIKBJq_coM</span></a></span><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Main Speaker</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535">: Cynthia Sharma, Professor, Institute
of Molecular Infection Biology (IMIB), University of Würzburg, Germany <span style="border:none windowtext 1.0pt;padding:0cm">(</span><a href="http://www.imib-wuerzburg.de/research/sharma/research/" target="_blank"><span style="border:none windowtext 1.0pt;padding:0cm;background:white">Link</span></a><span style="border:none windowtext 1.0pt;padding:0cm">)</span><o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:7.5pt;margin-left:0cm;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p> </o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Title: </span></strong><strong><span style="font-family:"Calibri",sans-serif;color:#7030A0;border:none windowtext 1.0pt;padding:0cm">Regulatory
RNAs in pathogenic Epsilonproteobacteria</span></strong><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:#7030A0;border:none windowtext 1.0pt;padding:0cm"><br>
<br>
</span></b><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Abstract</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">:</span><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:12.0pt;margin-left:0cm;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535">Non-coding RNAs and RNA-protein (RNP) complexes play central roles in diverse physiological processes in all kingdoms of life. Research in our lab focuses on RNA-based processes in
the two pathogenic Epsilonproteobacteria Helicobacter pylori, the cuasative agent of gastric cancer, and the related food-borne pathogen Campylobacter jejuni. We are especially interested in the roles of small, regulatory RNAs (sRNAs) and RNPs in virulence
control as well as novel mechanisms of gene regulation. For example, we have discovered new connections between so-called phase-variation at length variable DNA repeats and post-transcriptional regulation. I will present our work on sRNAs from H. pylori and
C. jejuni that target variable G-repeats and regulate genes involved in host colonization as well as antibiotic sensitivity. Moreover, we recently identified a sRNA that is itself regulated by a phase-variable repeat and acts as a central regulator of the
major virulence factors of H. pylori.<o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Short session speaker</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"> (8 minutes long): Fabian
König<o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"inherit",serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Title: </span></strong><strong><span lang="EN-GB" style="font-family:"Cambria",serif;color:#7030A0;border:none windowtext 1.0pt;padding:0cm">A
3´UTR-derived, processed small RNA modulates flagellar biogenesis by repression of the anti-sigma factor FlgM in </span></strong><em><b><span lang="EN-GB" style="font-size:11.0pt;font-family:"inherit",serif;color:#7030A0;border:none windowtext 1.0pt;padding:0cm">Campylobacter
jejuni</span></b></em><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p style="margin:0cm;margin-bottom:.0001pt;background:white;vertical-align:baseline;font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">Abstract</span></strong><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535;border:none windowtext 1.0pt;padding:0cm">:</span><span style="font-size:10.0pt;font-family:"Tahoma",sans-serif;color:#353535"><o:p></o:p></span></p>
<p class="MsoNormal" style="font-variant-ligatures: normal;font-variant-caps: normal;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;orphans: 2;widows: 2;-webkit-text-stroke-width: 0px;text-decoration-thickness: initial;text-decoration-style: initial;text-decoration-color: initial;word-spacing:0px">
<span lang="EN-GB" style="font-family:"Cambria",serif;color:black;border:none windowtext 1.0pt;padding:0cm;background:white">In <em><span style="font-family:"Cambria",serif">Campylobacter jejuni</span></em>, as for many pathogens, flagella are a crucial virulence
factor, enabling traversal through the viscous mucus layer of the human intestine. Flagellar biogenesis is known to involve hierarchical transcriptional control of each component, with class I genes transcribed from sigma-70-dependent promoters, and class
II and class III genes transcribed with the help of alternative sigma factors, RpoN and FliA, respectively. In contrast to transcriptional control, less is known about post-transcriptional regulation of flagellar biosynthesis cascades by small regulatory RNAs
(sRNAs). Here, we have characterized a conserved <em><span style="font-family:"Cambria",serif">Campylobacter</span></em> sRNA, CJnc230, encoded downstream of the RpoN-dependent flagellar hook structural protein FlgE, and found that three ribonucleases are
involved in sRNA maturation. RNase III cleaves off the sRNA from the <em><span style="font-family:"Cambria",serif">flgE</span></em> mRNA, while RNase Y and PNPase process CJnc230 at its 3´ end. We identified a regulator of flagella-flagella interactions as
well as the anti-sigma-28 factor FlgM as targets of CJnc230 repression. CJnc230 overexpression led to de-repression of FliA and subsequent upregulation of class III flagellar genes such as the major flagellin <em><span style="font-family:"Cambria",serif">flaA</span></em>,
culminating in an increase in motility and flagellar length. Overexpression of the FliA-dependent sRNA CJnc170 instead led to reduced motility suggesting sRNA-mediated regulation of <em><span style="font-family:"Cambria",serif">C. jejuni</span></em> flagellar
biosynthesis through balancing of the hierarchically expressed components.</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The club propose seminars every two months. Abstracts and links for the seminars are available here:
<span lang="FR"><a href="https://smallrna-bioinformatics.eu/Pages/Seminars/Seminars.aspx"><span lang="EN-US">https://smallrna-bioinformatics.eu/Pages/Seminars/Seminars.aspx</span></a></span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Tweet for easy re-transmission: <a href="https://twitter.com/Laurent_Guyon/status/1540352879780892672">
https://twitter.com/Laurent_Guyon/status/1540352879780892672</a><o:p></o:p></p>
<p class="MsoNormal">YouTube channel (most of the seminars are then shared through this channel,
<b>but not this one</b>): <span lang="FR"><a href="https://www.youtube.com/channel/UCTiHtqOKzneeqIqauQMgx3A"><span lang="EN-US">https://www.youtube.com/channel/UCTiHtqOKzneeqIqauQMgx3A</span></a></span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Seminars are given at 4pm CET, except in rare cases.<o:p></o:p></p>
<p class="MsoNormal">- 4 July 2022 - Cynthia Sharma - mechanisms/functions of <b>
small RNAs in bacteria</b><o:p></o:p></p>
<p class="MsoNormal">- 10 October 2022 (updated) - Marc Friedländer - <b>miRNA-target interactions in single cells</b><o:p></o:p></p>
<p class="MsoNormal">- 7 November 2022 - Amy Buck - Dr Buck is working in the field of
<b>microRNA-virus interactions</b><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">‘hope to see you virtually in these seminars,<o:p></o:p></p>
<p class="MsoNormal">Laurent Guyon, on behalf of all the organizers (Rolf Backofen, Ana Eulálio, Bastian Fromm, Laurent Guyon, Andreas Keller, Marie-France Sagot)<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:navy">____________________________<br>
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Laurent GUYON, PhD, HDR – Bioinformatics<br>
CEA IRIG (</span><span lang="FR"><a href="http://www.cea.fr/drf/IRIG/english/Pages/Presentation.aspx"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">Interdisciplinary Research Institute of Grenoble</span></a></span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">)<br>
BioHealth Department - BCI (</span><span lang="FR"><a href="http://www.bci-lab.fr/en"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">Biology of Cancer and Infection laboratory</span></a></span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">)<br>
</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">UMR 1292 CEA/Inserm/Université Grenoble Alpes</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"><br>
<br>
</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">CEA Grenoble - Bât C3 – Bureau 224<br>
17 rue des Martyrs - 38054 GRENOBLE Cedex 9 – France<br>
</span><span style="font-size:5.0pt;font-family:"Comic Sans MS",serif;color:navy"><br>
</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Tél : (+33)4.38.78.04.53 - Fax : (+33)4 38 78 50 58</span><span style="font-size:5.0pt;font-family:"Comic Sans MS",serif;color:navy"><br>
</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Email :
</span><span lang="FR"><a href="mailto:laurent.guyon@cea.fr"><span lang="EN-US" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">laurent.guyon@cea.fr</span></a></span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">
- </span><span lang="FR"><a href="http://laurent.guyon.phd.free.fr/"><span lang="EN-US" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">http://laurent.guyon.phd.free.fr/</span></a></span><u><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"><br>
<br>
</span></u><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Interested by small non-coding RNA bioinformatics? Join the
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:#C00000">club</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">!
</span><span lang="FR"><a href="https://smallrna-bioinformatics.eu/"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">https://smallrna-bioinformatics.eu/</span></a></span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"><br>
<br>
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:#C00000">Special issue
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">on small non-coding RNA bioinformatics, submit before the
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:red">15<sup>th</sup> of October</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"> (updated - contact me if you need delay):<br>
</span><span lang="FR"><a href="https://www.mdpi.com/journal/genes/special_issues/Small_RNA_Bioinformatics"><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">https://www.mdpi.com/journal/genes/special_issues/Small_RNA_Bioinformatics</span></a></span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"><br>
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Happy to share </span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:#C00000">miRViz
</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">(free to use website to analyze your microRNA datasets):
</span><span lang="FR"><a href="http://mirviz.prabi.fr/"><span lang="EN-US" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">http://mirviz.prabi.fr/</span></a></span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy"><br>
</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Article:</span><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif">
</span><a name="PANISTVisited"></a><a href="https://doi.org/10.1093/nar/gkaa259"><span style="mso-bookmark:PANISTVisited"><span style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue;border:none windowtext 1.0pt;padding:0cm;background:white">https://doi.org/10.1093/nar/gkaa259</span></span><span style="mso-bookmark:PANISTVisited"></span></a><span style="mso-bookmark:PANISTVisited"></span><br>
<span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:navy">Messages of the paper:</span><span lang="EN-GB" style="font-size:7.5pt;font-family:"Comic Sans MS",serif">
</span><span lang="FR"><a href="https://twitter.com/Laurent_Guyon/status/1255487510563651586"><span lang="EN-US" style="font-size:7.5pt;font-family:"Comic Sans MS",serif;color:blue">https://twitter.com/Laurent_Guyon/status/1255487510563651586</span></a></span><span style="font-size:5.0pt;color:navy;mso-fareast-language:JA"><o:p></o:p></span></p>
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