<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div><div style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space; position: relative;"><div>Dear colleagues,</div><div>there are PhD and postdoc positions available in my laboratory at the Max Planck Institute for Multidisciplinary Sciences in Goettingen/Germany. </div><div>I would be very grateful if you could share the ad and link below with suitable candidates.</div><div>Link to the job offer:</div><div><a href="https://www.mpinat.mpg.de/4634381/11-24">https://www.mpinat.mpg.de/4634381/11-24</a></div><div><div class="apple-rich-link" draggable="true" role="link" data-url="https://www.mpinat.mpg.de/4634381/11-24" style="-webkit-user-select: all; -webkit-user-drag: element; display: inline-block;"></div></div><div>Many thanks and best wishes,</div><div>Sonja Lorenz</div><br class="Apple-interchange-newline"><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;"> ===========================================</span></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;"><br></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">The research group <i>Ubiquitin Signaling Specificity</i> (Dr. Sonja Lorenz) invites applications for the position as<o:p></o:p></span></p><p class="MsoNormal" align="center" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;"><b><span lang="EN-GB" style="font-size: 14pt; font-family: "Times New Roman", serif;">PhD student or Postdoc (f/m/d)<o:p></o:p></span></b></p><p class="MsoNormal" align="center" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;"><b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">– </span></b><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Specificity mechanisms of ubiquitin ligase complexes </span></b><b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">–</span></b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Our laboratory aims to understand how the posttranslational modifier ubiquitin regulates myriad aspects of eukaryotic physiology<i>.</i> A major key lies in the action of ubiquitin ligases, a highly diversified enzyme class that recognizes specific substrates for ubiquitination and determines the types of modifications they are decorated with. The immense potential of ubiquitin ligases for therapeutic applications has been illustrated by the clinical efficacy of immunomodulatory drugs in the treatment of hematological malignancies and recent advances of Protacs/molecular glues. Yet, efficient targeting of ubiquitin ligases in the clinic is still hampered by our limited understanding of their structural mechanisms and integration into cellular pathways. <o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">We offer PhD or Postdoc positions to explore structure-function relationships in ubiquitin ligases. Building on strong preliminary data, available projects focus on (i) the isolation/ biochemical reconstitution of ubiquitin ligases complexes with substrates and regulators for cryo-EM analyses; (ii) the cell-based identification of ubiquitin ligase complexes and functional analyses; (iii) solution NMR analyses of the regulation and conformational dynamics of ubiquitination enzymes. Our projects typically combine several of the above-mentioned techniques and can be tailored to the particular interests of the successful candidate. For an example of our ongoing work, please see:<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;"> <u><a href="https://www.nature.com/articles/s41594-023-01203-4">https://www.nature.com/articles/s41594-023-01203-4</a></u><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">PhD candidates </span></b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">should </span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">hold/soon expect a MSc or equivalent degree in a relevant area of the life sciences. Initial experience in <i>one or more</i> of the following techniques is desired: protein biochemistry, mammalian cell biology, or any aspect of structural biology. <b><o:p></o:p></b></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Postdoctoral candidates </span></b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">should<b> </b></span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">have/soon expect a PhD or equivalent degree in a relevant area of the life sciences. A proven track record in either <i>cryo EM </i>or<i> solution NMR</i>, including experience in protein purification/isolation of protein complexes. <o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">The successful candidates for either position should be curiosity-driven, creative, and passionate about science. A high degree of self-motivation and independence is important, as well as the ability to communicate well within an international, multidisciplinary team.<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">We offer<o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm 0cm 0cm 35.7pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; text-indent: -17.85pt;"><span lang="EN-US" style="font-size: 12pt; font-family: Symbol;">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal;"> </span></span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">competitive research in an inspiring, world-class environment<o:p></o:p></span></p><ul type="disc" style="margin-bottom: 0cm;"><li class="MsoNormal" style="margin: 0cm 0cm 8pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">professional training, networking and career-development opportunities; free language courses<o:p></o:p></span></li></ul><p class="MsoNormal" style="margin: 0cm 0cm 8pt 35.7pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; text-indent: -17.85pt;"><span lang="EN-US" style="font-size: 12pt; font-family: Symbol;">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal;"> </span></span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">on-site health management: free fitness and yoga room, sports groups, beach volleyball league, and courses for a "moving lunch break”<o:p></o:p></span></p><ul type="disc" class="MailOutline" style="margin-bottom: 0cm;"><li class="MsoNormal" style="margin: 0cm 0cm 8pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">a wide range of opportunities to balance work and family life, including an on-campus kindergarten and vacation care<o:p></o:p></span></li><li class="MsoNormal" style="margin: 0cm 0cm 8pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">spacious on-site cafeteria offering warm meals and a salad bar<o:p></o:p></span></li></ul><p class="MsoNormal" style="margin: 0cm 0cm 6pt 35.7pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify; text-indent: -17.85pt;"><span lang="EN-US" style="font-size: 12pt; font-family: Symbol;">·<span style="font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman"; font-size-adjust: none; font-kerning: auto; font-variant-alternates: normal; font-variant-ligatures: normal; font-variant-numeric: normal; font-variant-east-asian: normal; font-variant-position: normal; font-feature-settings: normal; font-optical-sizing: auto; font-variation-settings: normal;"> </span></span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">initiatives for sustainability and a green environment, including an on-site biotope</span></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">About us<o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Based at one of Germany’s premier research campuses, our research group has access to leading-edge infrastructure in all areas of cell and structural biology, including cryo-EM. We are an international team, supported by the Max Planck Society, the German Research Foundation, and the EMBO Young Investigator Program. Our working language is English; knowledge of German is not required. The historic city of Göttingen, located in the center of Germany, offers great outdoor and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Position details</span></b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">The positions should be filled as soon as possible; the </span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;">exact start date is flexible. </span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;">PhD students will be funded for three years (with a possibility of extension) and have the opportunity to enroll in one of several PhD programs in collaboration with the University of G</span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;">ö</span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;">ttingen. Fast-track MSc/PhD students are also welcome to apply. Postdoc positions are initially funded for two years with a possibility of extension. </span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Payment and benefits are based on the TV</span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;">ö</span><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">D (wage agreement for public service personell) guidelines. </span><span lang="EN-US" style="font-size: 12pt; font-family: Times, serif;"><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Application </span></b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Please submit your application including a cover letter (explaining background and motivation), CV, academic transcripts, publication list, and the contact addresses of two preferably references <i>as a single PDF file</i> to the email address below. Review of applications will begin immediately. <o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="DE"><a href="mailto:ausschreibung11-24@mpinat.mpg.de" style="color: rgb(149, 79, 114);"><b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">ausschreibung11-24@mpinat.mpg.de</span></b></a></span><b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span style="position: relative; z-index: 251661312;"><span style="position: absolute; left: 433px; top: -269px; width: 85px; height: 85px;"><br></span></span><b><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">Max Planck Institute for Multidisciplinary Sciences <o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Research Group Ubiquitin Signaling Specificity</span></b><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Dr. Sonja Lorenz</span></b><b><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;"><o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="DE" style="font-size: 12pt; font-family: "Times New Roman", serif;">Am Faßberg 11 <o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="DE" style="font-size: 12pt; font-family: "Times New Roman", serif;">37077 Göttingen <o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><b><span lang="DE" style="font-size: 12pt; font-family: "Times New Roman", serif;">Germany<o:p></o:p></span></b></p><p class="MsoNormal" style="margin: 0cm 0cm 3pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="DE" style="font-size: 12pt; font-family: "Times New Roman", serif;">Web: </span><span lang="DE"><a href="https://www.mpinat.mpg.de/lorenz" style="color: rgb(149, 79, 114);"><span style="font-size: 12pt; font-family: "Times New Roman", serif;">https://www.mpinat.mpg.de/lorenz</span></a></span><span lang="DE" style="font-size: 12pt;"><o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm 0cm 6pt; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-US" style="font-size: 12pt; font-family: "Times New Roman", serif;">Twitter: SLorenzLab<o:p></o:p></span></p><p class="MsoNormal" style="margin: 0cm; line-height: normal; font-size: 11pt; font-family: Calibri, sans-serif; text-align: justify;"><span lang="EN-GB" style="font-size: 12pt; font-family: "Times New Roman", serif;">Information pursuant to Article 13 DS-GVO on the collection and processing of personal data during the application process can be found on our website below the respective job advertisement.</span></p></div></div></body></html>