<div dir="ltr"><br id="gmail-docs-internal-guid-ada2679c-7fff-e1d2-db28-16a0897065e3"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">The three-dimensional (3D) structure dictates its function and can facilitate mechanistic understanding of biological processes. The recent advances in Artificial Intelligence (AI)-based methods, such as AlphaFold and RoseTTaFold, provide high-quality structure models for biomacromolecules (proteins and nucleic acids) and their complexes small molecule ligands and have transformed basic and translational life science research.  The predicted models offer deeper insights into the functional sites and interaction surfaces underpinning their biological roles. </span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Elofsson and Velankar teams are interested in exploring some of the computational challenges in employing AI-based methods for predicting large biomacromolecular complexes and generate a set of high-quality structure models. This will be achieved by refining the strategies for predicting larger biomacromolecular complexes (more than two subunits) and cataloguing the biomacromolecular interactions in the human proteome. To make the structural data accessible and valuable in driving life science research, we are interested in exploiting knowledge graphs (KG) techniques to enrich the data with structural and functional annotations. The KG will allow reasoning over the annotations and knowledge transfer across related proteins by providing a structured representation of known annotations through nodes and edges.</span></p><br><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">The method developed within this ARISE2 project will be tested with data and biological questions arising at the EMBL and SciLifeLab cryo-EM and integrative structural biology</span><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:rgb(255,242,204);font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> </span><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">facilities and will be useful for a large community of researchers in structural biology. </span></p><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> </span></p><h3 dir="ltr" style="line-height:1.38;margin-top:16pt;margin-bottom:4pt"><span style="font-size:14pt;font-family:Arial,sans-serif;color:rgb(67,67,67);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">ARISE2 (<a href="https://www.embl.org/training/arise2/">https://www.embl.org/training/arise2/</a>)</span></h3><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">ARISE2 targets technology and method development experts with STEM backgrounds interested in using their expertise to advance research in the life sciences.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">To address urgent challenges to human and planetary health, new technologies and services are needed in the Life Sciences. ARISE2 is designed to meet this need by training fellows in the development of technologies and methods for the improvement of scientific services while also preparing them for careers in research infrastructures (RI) to make these advances available to the scientific community, accelerating progress.  </span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">ARISE2 is an MSCA-funded postdoctoral fellowship programme offering talented STEM (science, technology, engineering and mathematics) fellows from around the world the unique opportunity to work on the development and/or improvement of technologies for Life Science Research while developing the expertise needed for a career in research infrastructures making them sought after experts both in academia and industry.</span></p><h3 dir="ltr" style="line-height:1.38;margin-top:16pt;margin-bottom:4pt"><span style="font-size:14pt;font-family:Arial,sans-serif;color:rgb(67,67,67);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Location of this position</span></h3><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">This position is primarily located at EMBL-EBI, Cambridge, UK, but extensive time will also be allocated to working with the researchers at the Science for Life Laboratory, Stockholm, Sweden. The fellow will visit the Science for Life Laboratory, Stockholm, Sweden. The position is for three years. </span></p><h3 dir="ltr" style="line-height:1.38;margin-top:16pt;margin-bottom:4pt"><span style="font-size:14pt;font-family:Arial,sans-serif;color:rgb(67,67,67);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Application</span></h3><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Please send a two-page CV and a two-page project proposal within the area outlined above to Sameer Velankar <</span><a href="mailto:sameer@ebi.ac.uk" style="text-decoration:none"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(17,85,204);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap">sameer@ebi.ac.uk</span></a><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">> by Nov 5, 2024.  The two-page proposal should cover the following areas -</span></p><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Background, proposed project</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Expected results & their impact</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Service to be offered</span></p></li><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Consideration of FAIR principals</span><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"><br></span><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> </span></p></li></ul><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">This is a pre-proposal. In the second step, we will select one candidate by November 12 at the latest, and together with the candidate, we will submit a full proposal by the deadline for the ARISE2 call on November 25.</span></p><h3 dir="ltr" style="line-height:1.38;margin-top:16pt;margin-bottom:4pt"><span style="font-size:14pt;font-family:Arial,sans-serif;color:rgb(67,67,67);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Contacts:</span></h3><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">More information about the ARISE2 program can be found at <a href="https://www.embl.org/training/arise2/">https://www.embl.org/training/arise2/</a></span></p><br><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">For this application</span></p></li><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="list-style-type:circle;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Marta Carroni <</span><a href="mailto:marta.carroni@scilifelab.se" style="text-decoration:none"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(17,85,204);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap">marta.carroni@scilifelab.se</span></a><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">></span></p></li><li dir="ltr" style="list-style-type:circle;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Sameer Velankar <</span><a href="mailto:sameer@ebi.ac.uk" style="text-decoration:none"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(17,85,204);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap">sameer@ebi.ac.uk</span></a><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">> </span></p></li><li dir="ltr" style="list-style-type:circle;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">Arne Elofsson <</span><a href="mailto:arne@bioinfo.se" style="text-decoration:none"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(17,85,204);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap">arne@bioinfo.se</span></a><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">> </span></p></li></ul><li dir="ltr" style="list-style-type:disc;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap">For questions about  the ARISE2 program</span></p></li><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="list-style-type:circle;font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt" role="presentation"><a href="mailto:arise2@embl.org" style="text-decoration:none"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(17,85,204);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:underline;vertical-align:baseline;white-space:pre-wrap">arise2@embl.org</span></a><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(0,0,0);background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre-wrap"> </span></p></li></ul></ul><br><br><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"> <br>Yours<br><br>Arne<br><i><br></i>-----------------------------------------<br>  Arne Elofsson                  Science for Life Laboratory<br>  Tel:+46-(0)70 695 1045   Stockholm University<br>  <a href="http://bioinfo.se/" target="_blank">http://bioinfo.se/</a>               Box 1031, <br>  Email: <a href="mailto:arne@bioinfo.se" target="_blank">arne@bioinfo.se</a>   17121 Solna, Sweden<br>  Twitter:   <a href="https://twitter.com/arneelof" target="_blank">https://twitter.com/arneelof</a></div><div dir="ltr">  Zoom: <span style="display:inline-flex"><a href="https://stockholmuniversity.zoom.us/my/arneelof/" target="_blank">https://stockholmuniversity.zoom.us/my/arneelof/</a><span></span></span><br>  Scholar: <a href="http://scholar.google.se/citations?user=s3OCM3AAAAAJ" target="_blank">http://scholar.google.se/citations?user=s3OCM3AAAAAJ</a><br>  ORCID: 0000-0002-7115-9751</div></div></div></div></div></div>