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<div class="">DDLS Industry PhD studentship in bioinformatics:<br>
Deep learning modeling of spatial biology data for expression
profile based drug repurposing <br>
<br>
A new exciting opportunity is combining spatial biology with
AI-driven modeling of gene expression responses to drug treatment
in the field of drug repurposing. Drug repurposing involves
identifying new therapeutic uses for existing medications, a
strategy that can significantly reduce the time and cost required
to bring a drug to market. The project will use AI models such as
CycleGANs, that by learning from complex spatial gene expression
profiles and cellular heterogeneity within tissues can predict how
existing drugs might act on previously uncharacterized disease
mechanisms or cellular subtypes. These models will be employed to
translate spatial gene expression profiles from healthy tissues to
disease states, and vice versa. This capability allows researchers
to simulate the effects of drug treatments on spatially resolved
gene expression without the need for extensive experimental data.
By learning the underlying mappings between these domains,
synthetic data will be generated that reflects potential drug
responses, thereby enhancing the predictive power of our models. <br>
<br>
This is an Industry PhD Project which is a collaboration between
Stockholm University and Merck AB. The PhD student will be
employed by Merck AB but registered and accepted to the PhD
program at Stockholm University. The project will have a base in
the Sonnhammer group at Science for Life Laboratory in Stockholm,
Sweden, which is a strong research environment for large-scale
life science research, and a joint physical center for a number of
computational and life science groups at Stockholm University,
KTH, and Karolinska Institutet. The research project will be
supervised by Professor Erik Sonnhammer and Dr. Dimitri Guala.</div>
<div class=""><br>
</div>
<div class="">Data-driven life science (DDLS) uses data,
computational methods and artificial intelligence to study
biological systems and processes at all levels, from molecular
structures and cellular processes to human health and global
ecosystems. The SciLifeLab and Wallenberg National Program for
Data-Driven Life Science (DDLS) aims to recruit and train the next
generation of data-driven life scientists and to create globally
leading computational and data science capabilities in Sweden. The
program is funded with a total of 3.3 billion SEK (about 290 M
USD) over 12 years from the Knut and Alice Wallenberg (KAW)
Foundation.<br>
<br>
In 2025 the DDLS Research School will be expanded with the
recruitment of 19 academic and 7 industrial PhD students. During
the DDLS program more than 260 PhD students and 200 postdocs will
be part of the Research School. The DDLS program has four
strategic research areas: cell and molecular biology, evolution
and biodiversity, precision medicine and diagnostics, epidemiology
and biology of infection. For more information, please see
scilifelab.se/data-driven/ddls-research-school/ <br>
<br>
The future of life science is data-driven. Will you be part of
that change? Then join us in this unique program!<br>
<br>
</div>
<div class=""> See ad at <a class="moz-txt-link-freetext"
href="https://sonnhammer.org/download/ads/open.html">https://sonnhammer.org/download/ads/open.html</a>
Deadline August 15<br>
<br>
To apply, follow the instructions on
<a class="moz-txt-link-freetext" href="https://careers.merckgroup.com/global/en/job/288421/Industrial-PhD-student-in-Bioinformatics">https://careers.merckgroup.com/global/en/job/288421/Industrial-PhD-student-in-Bioinformatics</a>.</div>
<br>
Thanks for spreading to potentially interested persons.<br class="">
<br>
Best Regards,<br>
<font size="-1">___________________________________<br>
</font><font size="-1">Erik Sonnhammer, Ph.D.<br>
Professor of Bioinformatics<br>
DBB, Stockholm University<br>
<a href="https://www.scilifelab.se/" moz-do-not-send="true">Science
for Life Laboratory</a><br>
Stockholm, Sweden<br>
Email: <a class="moz-txt-link-abbreviated moz-txt-link-freetext"
href="mailto:Erik.Sonnhammer@scilifelab.se"
moz-do-not-send="true">Erik.Sonnhammer@scilifelab.se</a><br>
</font><font size="-1"><a class="moz-txt-link-freetext"
href="https://sonnhammer.org" moz-do-not-send="true">https://sonnhammer.org</a></font><br>
<font size="-1"> </font><font size="-1"><a
href="https://x.com/eriksonnhammer"
class="moz-txt-link-freetext" moz-do-not-send="true">https://x.com/eriksonnhammer</a></font>
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