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<p><b>Doktorand / PhD position: Bioinformatics and Mechanistic
Modelling for Precision Medicine, Örebro University, Schweden</b><br>
<br>
Deadline for application: <br>
2025-10-31<br>
<br>
Website for application:<br>
<a class="moz-txt-link-freetext" href="https://www.oru.se/english/career/available-positions/job/?jid=20250281">https://www.oru.se/english/career/available-positions/job/?jid=20250281</a><br>
<br>
Join the X-HiDE/ROSETTA research collaboration to develop and
evaluate hybrid modelling approaches that integrate mechanistic
models of inflammation and diet-inflammation interactions with
statistical models using large-scale molecular data. The project
aims to improve disease phenotype classification and deepen
mechanistic understanding across inflammation driven complex
diseases, and dietary response types. This interdisciplinary work
connects bioinformatics and systems biology approaches with
precision medicine, and responsive nutrition, and is integrated
with international and industry partners.<br>
<br>
The PhD position is located at the School of Medical Sciences
(MV), Örebro University, a modern and expanding university with
approximately 1,600 employees and 17,000 students. MV also hosts
the university's medical program and drives several research
centers primarily focused on inflammation, metabolism, and
nutrition.<br>
<br>
X-HiDE, Exploring Inflammation in Health and Disease, is a
strategic research initiative at Örebro University. Using a
systems-analytical approach, and employing different kinds of
modelling approaches, X-HiDE explores the mechanisms of
inflammation across different diseases to investigate shared and
distinct inflammatory phenotypes. The Research Center Responsive
Nutrition, ROSETTA@oru, is a multidisciplinary research initiative
focused on the complex interactions between diet and human gut,
metabolic and mental health. By combining advanced molecular
analysis with clinical studies, ROSETTA aims to identify how and
when individual differences affect dietary health effects. The
project explores how food can be used as a tool to prevent or
manage inflammation-mediated disorders, such as IBS, IBD and
various mental disorders and supports the development of
personalized nutrition strategies. Both environments are part of
Örebro University's new Center for Food and Health and bring
together interdisciplinary expertise and collaborate closely
together and with academic, clinical, and industrial partners to
advance precision medicine and translational research. The
Bioinformatics group at Örebro University is an integrated part of
both centres, with focus on new methods for analysing and
modelling molecular data, cellular mechanisms and clinical
phenotypes, based on both statistics/machine learning and
computational mechanistic modelling. The group specializes in
analysing complex OMICs datasets (e.g., transcriptomics,
proteomics, microbiota) to uncover biosignatures and causal
mechanisms in health and disease. Their work connects systems
biology, statistical learning, and translational medicine, with
applications in inflammation research, gut-brain interactions, and
personalized nutrition.<br>
<br>
Supervision: You will be supervised by Dirk Repsilber (prof
bioinformatics, principal supervisor) and a team of assistant
supervisors from both research platforms, X-HiDE and Rosetta.<br>
<br>
The doctoral programme consists of courses and an independent
research project that you will present in a doctoral thesis. The
programme concludes with a doctoral degree and comprises 240
credits, which corresponds to four years of full-time study.<br>
<br>
Our ambition is to enable stimulating and purposeful doctoral
studies for you, throughout the programme, until you have obtained
your doctoral degree. A thorough introduction will therefore get
you off to a good start and provide a solid foundation on which
you can build your studies. As a doctoral student at Örebro
University, you will be offered a specially tailored seminar
series, covering matters ranging from doctoral programme rules and
careers to support during the study period and networking. You
will be offered to join the national Graduate School MedBioInfo,
for advanced courses in Bioinformatics and networking on a
national level.<br>
<br>
The place on the programme is linked to a full-time doctoral
studentship for the duration of the study programme, which
corresponds to four years of full-time study. More information on
doctoral studentships, part-time studies and part-time doctoral
studentships can be found in the Regulations Handbook. The initial
salary for a doctoral studentship is SEK 31,300 a month.<br>
<br>
For more information about the programme and the doctoral
studentship, contact Professor Dirk Repsilber
(<a class="moz-txt-link-abbreviated" href="mailto:dirk.repsilber@oru.se">dirk.repsilber@oru.se</a>).</p>
<pre class="moz-signature" cols="72">--
______________________________________________________
Dirk Repsilber
Bioinformatics
School of Medical Sciences (MV)
University of Örebro
S - 701 82 Örebro
Sweden
+46 73 270 7633
<a class="moz-txt-link-freetext" href="https://www.oru.se/personal/dirk_repsilber">https://www.oru.se/personal/dirk_repsilber</a>
______________________________________________________</pre>
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