<div dir="ltr"><div><br clear="all"></div><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div> From Frank Noe</div><div dir="ltr"><br></div><div>see: <a href="https://aka.ms/bioemu-applied" target="_blank">aka.ms/bioemu-applied</a></div><div dir="ltr"><br></div><div dir="ltr"><br></div><div dir="ltr"><div>Basicly we’re
looking for a computational biologist / bioinformatician who would
enjoy
running and automating BioEmu and other structure-based tools and
databases on
very large scale and creating structure-based models of dynamics
of entire
pathways or proteomes. The person should be quite technical and
have a good
understanding of structural biology (tricky combination).</div>
<div>The person
will also co-lead a partnership with a drug discovery collaborator
who will
bring in lots of experimental data to train the next BioEmu
version and be responsible
for helping to make the connection between experimentalists and ML
researchers.</div>
<div> </div>
<div>Do you know
anyone who might be a fit and is available? They need to have a
PhD (or expect
it soon), but they could be significantly more senior.</div><br><h1 style="font-weight:700;font-size:26px;margin-bottom:16px;margin-top:0px;color:rgb(0,0,0)">Senior Applied Researcher - MSR AI for Science</h1><div style="margin-bottom:24px" class="gmail-ms-Stack gmail-css-472"><div class="gmail-ms-Stack-inner gmail-css-471"><p style="margin:0px;font-weight:400;font-size:14px;padding-top:2px">Multiple Locations, Germany</p><button type="button" aria-label="1 more locations where job is available" id="gmail-calloutId26" style="display:inline-block;margin-top:2px;text-decoration:none" class="gmail-ms-Link gmail-root-473"><span style="color:rgb(92,27,134);margin:0px 0px 0px 2px;padding-left:3px;font-weight:400;font-size:14px;text-decoration:none;padding-right:5px">+ 1 more location</span></button></div></div><div style="width:100%" class="gmail-ms-Stack gmail-css-418"><div class="gmail-ms-Stack gmail-css-474"><div id="gmail-ms-search-jobdescription-save-job-callout-188574627" 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style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">Oct 01, 2025</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Job number</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">1885746</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Work site</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">3 days / week in-office</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Travel</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">0-25 %</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Role type</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">Individual Contributor</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Profession</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">Research, Applied, & Data Sciences</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Discipline</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">Research Sciences</div></div></div><div class="gmail-IyCDaH20Khhx15uuQqgx"><div style="padding-top:9px;padding-bottom:9px;padding-right:9px;word-break:break-word" class="gmail-ms-Stack gmail-css-412"><div style="width:36%;font-weight:400;font-size:14px;color:rgb(96,94,92);padding-right:9px" class="gmail-ms-Stack gmail-css-418">Employment type</div><div style="width:64%;font-weight:600;font-size:14px;color:rgb(23,23,23)" class="gmail-ms-Stack gmail-css-418">Full-Time</div></div></div></div><hr class="gmail-horizontalLine-278"><div class="gmail-fcUffXZZoGt8CJQd8GUl"><div class="gmail-MKwm2_A5wy0mMoh9vTuX"><div class="gmail-ms-Stack gmail-css-418"><h3 style="font-weight:600;font-size:18px;line-height:24px;color:rgb(23,23,23)">Overview</h3><div><p style="margin:0px">At <a href="https://www.microsoft.com/en-us/research/lab/microsoft-research-ai-for-science" target="_blank" rel="noopener">Microsoft Research AI for Science</a>,
we believe machine learning and artificial intelligence has the
potential to transform scientific modelling and discovery crucial for
solving the most pressing problems facing society including sustainable
materials and discovery of new drugs.</p><p style="margin:0px">We seek
a highly motivated Senior Applied Researcher to join our Biomolecular
Emulator (BioEmu) team. The BioEmu project aims to model the dynamics
and function of proteins - how they change shape, bind to each other,
and bind small molecules. This approach will help us to understand
biological function and dysfunction on a structural level and lead to
more effective and targeted drug discovery. Our BioEmu-1 model was
published in <a href="https://www.science.org/doi/10.1126/science.adv9817" target="_blank" rel="noopener">Science</a> (see our <a href="https://www.microsoft.com/en-us/research/blog/exploring-the-structural-changes-driving-protein-function-with-bioemu-1" target="_blank" rel="noopener">blog post</a> for links to our open-source software and other resources and this <a href="https://www.youtube.com/watch?v=LStKhWcL0VE" target="_blank" rel="noopener">explainer video</a>). </p></div></div></div><div class="gmail-WzU5fAyjS4KUVs1QJGcQ"><div class="gmail-ms-Stack gmail-css-418"><h3 style="font-weight:600;font-size:18px;line-height:24px;color:rgb(23,23,23)">Qualifications</h3><div><p style="margin:0px"><span>Required:</span></p><ul><li>PhD or equivalent research experience in Chemistry, Biophysics, Physics, Computer Science, Bioinformatics or a related field. </li><li>Demonstrated
passion and proven excellence in computational molecular biology,
biophysics, or bioinformatics via impactful projects, publications, or
open‑source code.</li><li>Experience with biomolecular
modeling/bioinformatics (e.g., folding systems, structural analysis, MD
simulation, structure/genome databases).</li><li>Excellent technical communication for interdisciplinary work.</li><li>Comfortable with real‑world data that lack structure/cleanliness/completeness.</li><li>Proficiency in Python and data analysis packages (NumPy, SciPy, Pandas).</li></ul><p style="margin:0px"><span>Preferred:</span></p><ul><li><span>Experience with deep learning methods and software packages (PyTorch, JAX, Tensorflow). <br></span></li><li><span>Experience
with structural biology or molecular biology data/techniques (e.g.,
cryo‑EM, binding assays, spectroscopy, expression, sequencing).<br></span></li><li><span>Background or advanced training in structural biology; familiarity with structure prediction and/or MD work-flows.<br></span></li></ul><p style="margin:0px"><span>#Research #AI for Science</span></p><p style="margin:0px"> </p><p style="margin:0px"><span></span></p><p style="margin:0px"> </p><p style="margin:0px"><span>In
line with our Flexible Work approach, for roles at Microsoft Germany,
we recommend spending at least two days per week in the office or at the
customer site. The actual number of days to work from the office or at
the customer will be defined in agreement between the employee and their
manager.</span></p></div></div></div><div class="gmail-MKwm2_A5wy0mMoh9vTuX"><div class="gmail-ms-Stack gmail-css-418"><h3 style="font-weight:600;font-size:18px;line-height:24px;color:rgb(23,23,23)">Responsibilities</h3><div><ul><li>Model
biomolecular structure and dynamics at scale: Use BioEmu,
structure/sequence databases, and complementary tools to analyze
proteins and complexes.</li><li>Innovate and improve analysis
technologies: Develop and implement scalable technologies to analyze and
quantify conformational transitions, structural flexibility, and
changes in complex formation for many biomolecular complexes.</li><li>Generate
biological hypotheses and insights: Integrate biomolecular structure
and dynamics data to generate experimentally-testable predictions and
biological insights.</li><li>Collaborate with experimentalists:
collaborate with wetlab scientists to test computational predictions.
Learn to read and interpret their data and work together to challenge
and improve hypothesis of biomolecular function.</li><li>Support
drug‑targeting strategies: Partner with leading drug discovery experts
to identify targets and propose mechanisms of action.</li><li>Operationalize
at scale: Build robust Python pipelines; automate large‑scale inference
and analysis jobs on Azure with reproducible work-flows.</li><li>Partner
across disciplines: communicate clearly with ML researchers and
experimental/computational biologists; present results and influence
project direction. </li><li>Work autonomously and as a team player, regularly reporting insights, risks, and next steps. </li><li>Aim
for impact: translate findings into artifacts others can use (code,
datasets, internal reports, and when appropriate - papers).</li></ul></div></div></div></div><hr class="gmail-horizontalLine-278"><div style="padding:30px 0px;font-size:14px" class="gmail-ms-Stack gmail-css-418"><div style="padding:0px 0px 30px" class="gmail-ms-Stack gmail-css-418"><span>Benefits/perks listed below may vary depending on the nature of your employment with Microsoft and the country where you work.</span></div><div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Industry leading healthcare" class="gmail-ms-Icon gmail-root-268 gmail-css-479 gmail-css-325" style="font-family:"FabricMDL2Icons-4""></i>Industry leading healthcare</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Educational resources" class="gmail-ms-Icon gmail-root-268 gmail-css-481 gmail-css-325" style="font-family:"FabricMDL2Icons-1""></i>Educational resources</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Discounts on products and services" class="gmail-ms-Icon gmail-root-268 gmail-css-393 gmail-css-325" style="font-family:"FabricMDL2Icons""></i>Discounts on products and services</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Savings and investments" class="gmail-ms-Icon gmail-root-268 gmail-css-479 gmail-css-325" style="font-family:"FabricMDL2Icons-4""></i>Savings and investments</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Maternity and paternity leave" class="gmail-ms-Icon gmail-root-268 gmail-css-483 gmail-css-325" style="font-family:"FabricMDL2Icons-17""></i>Maternity and paternity leave</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Generous time away" class="gmail-ms-Icon gmail-root-268 gmail-css-485 gmail-css-325" style="font-family:"FabricMDL2Icons-3""></i>Generous time away</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Giving programs" class="gmail-ms-Icon gmail-root-268 gmail-css-393 gmail-css-325" style="font-family:"FabricMDL2Icons""></i>Giving programs</span></div><div class="gmail-KDE7kZPL_kjXdvl00Oro"><span><i role="img" aria-label="Opportunities to network and connect" class="gmail-ms-Icon gmail-root-268 gmail-css-487 gmail-css-325" style="font-family:"FabricMDL2Icons-8""></i>Opportunities to network and connect</span></div></div></div><hr class="gmail-horizontalLine-278"><div style="padding:10px 0px" class="gmail-ms-Stack gmail-RDEGRt3Q60YO2Yqjs8r4 gmail-css-418"><div style="font-weight:400;font-size:12px;line-height:16px;color:rgb(100,100,100);padding:10px 0px" class="gmail-ms-Stack gmail-css-418"><span>Microsoft
is an equal opportunity employer. All qualified applicants will receive
consideration for employment without regard to age, ancestry,
citizenship, color, family or medical care leave, gender identity or
expression, genetic information, immigration status, marital status,
medical condition, national origin, physical or mental disability,
political affiliation, protected veteran or military status, race,
ethnicity, religion, sex (including pregnancy), sexual orientation, or
any other characteristic protected by applicable local laws, regulations
and ordinances. If you need assistance and/or a reasonable
accommodation due to a disability during the application process, read
more about <a href="https://careers.microsoft.com/v2/global/en/accessibility.html">requesting accommodations</a>.</span></div></div><div style="height:auto;padding-bottom:20px" class="gmail-ms-Stack gmail-css-418"><div class="gmail-ms-Stack gmail-css-474"><div style="width:100%" class="gmail-ms-Stack gmail-css-418"><div class="gmail-ms-Stack gmail-css-474"><br></div></div></div></div>Yours<br><br>Arne<br><i><br></i>-----------------------------------------<br> Arne Elofsson Science for Life Laboratory<br> Tel:+46-(0)70 695 1045 Stockholm University<br> <a href="http://bioinfo.se/" target="_blank">http://bioinfo.se/</a> Box 1031, <br> Email: <a href="mailto:arne@bioinfo.se" target="_blank">arne@bioinfo.se</a> 17121 Solna, Sweden<br></div><div>Bluesky: @<a href="http://bioinfo.se" target="_blank">bioinfo.se</a> </div><div dir="ltr">Twitter/X: @arneelof<br></div><div dir="ltr"> Mastodon: @<a href="mailto:arneelof@fediscience.org" target="_blank">arneelof@fediscience.org</a><br></div><div dir="ltr"> Zoom: <span style="display:inline-flex"><a href="https://stockholmuniversity.zoom.us/my/arneelof/" target="_blank">https://stockholmuniversity.zoom.us/my/arneelof/</a><span></span></span><br> Scholar: <a href="http://scholar.google.se/citations?user=s3OCM3AAAAAJ" target="_blank">http://scholar.google.se/citations?user=s3OCM3AAAAAJ</a><br> ORCID: <a href="https://orcid.org/0000-0002-7115-9751" target="_blank">0000-0002-7115-9751</a></div></div></div></div></div></div>