[SocBiN] Postdoc in Protein Evolution

David Liberles liberles at uwyo.edu
Wed Aug 22 18:01:03 CEST 2012


Postdoctoral Research Associate: Molecular Evolution of Protein-Protein
Interaction Sites in Chordates


An NIH-funded 2 year postdoctoral research position is available
immediately for a collaborative project between the research groups of
Dietlind Gerloff (UCSC; http://users.soe.ucsc.edu/~gerloff/), David
Liberles (University of Wyoming;
http://www.wyomingbioinformatics.org/LiberlesGroup/) and Seth Rubin
(UCSC; http://www.chem.ucsc.edu/~srubin). The position is ideally suited
for researchers with interests and experience in studying protein
function computationally and experimentally, from structural and
evolutionary perspectives.


Our collaboration aims to cast new light on the adaptability of protein
interaction networks through detailed consideration of individual
protein families and interactions. The project will initially involve
large-scale computational comparative analysis of sequences in a protein
structural context using novel phylogenetic methods. The resulting data
will serve to predict evolutionary interesting changes in
protein-protein interactions between closely related species that will
be validated computationally and experimentally. 


The successful candidate will have a Ph.D. degree (preferably in
computational or experimental biology, biochemistry, or chemistry) and
demonstrated expertise in several of the relevant disciplines and skills
below.

      * The field of molecular evolution, including statistical and
        modeling approaches
        
      * Protein sequence analysis and structural bioinformatics,
        including force fields
        
      * Strong programming skills (perl, Python, C++)
        
      * Experimental molecular biology (preferably protein biochemistry)
        
      * Strong oral and written communication skills 
        


The salary is negotiable in the range $45,000-$60,000 plus benefits,
depending upon experience. Prior postdoctoral experience is a plus and
will result in salaries towards the upper end of the indicated range.


The researcher will be based at UCSC (Santa Cruz, CA), but s/he will be
expected to spend part of the 2 year research period at the University
of Wyoming (Laramie, WY). Evaluation of applications will begin
immediately and the candidate will be available to start as soon as
possible (no later than within 3 months). The position may be extended
beyond 2 years if additional funding is available.


To apply, send a cover letter that describes your background,
motivation, and interests accompanied by a full CV to
gerloff at soe.ucsc.edu and liberles at uwyo.edu (applications should be sent
to both email addresses). Please also arrange to have 3 letters of
recommendation sent directly by the letter writer to the above email
addresses. Minority, female, and international applicants are encouraged
to apply and will be given full consideration.




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