[Socbin] Postdoc in Systems Biology: ”Network medicine approach to cancer progression”

[Rune Linding]

*Dear all,*
*
*
*the deadline for this job is March 5th, Please forward to potential
candidates.*
*
*
*Best wishes,*
*Rune*
*
*
*URL:
http://www.dtu.dk/English/About_DTU/vacancies.aspx?guid=bddb0bc4-11c4-444d-b3a7-43a50da82185
*



The Cellular Signal Integration Group (C-SIG) is a network biology research
group located at the Center for Biological Sequence Analysis (CBS) at the
Technical University of Denmark (DTU). The center was formed in 1993 to
conduct basic research in the fields of bioinformatics and subsequently
systems biology and is divided into twelve specialist research groups. CBS
represents one of the largest computational biology centers in academia in
Europe and has a highly multi-disciplinary profile (biologists,
biochemists, MDs, physicists, statisticians, and computer scientists) with
a ratio of 2:1 of bio- to nonbio- backgrounds. In C-SIG, we explore
biological systems by developing and deploying algorithms aimed to predict
cell behavior with accuracy similar to that of weather or aircraft models.
Our focus is on studying cellular signal processing and decision-making.

*Job description
*A Postdoc position is available in Dr Rune Linding’s Cellular Signal
Integration Group (C-SIG,http://www.lindinglab.org) at CBS. Dr Linding is a
world-leading network and systems biologist whose laboratory is interested
in the mechanisms by which cells use signaling networks to respond to
changes in their environment. We are seeking highly motivated, bright
researchers and our lab is a dynamic, highly productive and stimulating
environment, where we provide world-class multi-disciplinary training.

In this position, the successful applicant will work in a fast-paced
dynamic environment performing studies to advance research into biological
systems, in order to develop new understanding and therapies of complex
human diseases like cancer.

We are seeking an experienced and motivated Postdoc to work on a project
related to our recent studies on phosphorylation networks (Bakal, Linding
et al. Science 2008, Tan et al. Science 2009 and 2011, Tan et al. Science
Signaling 2009 and Jørgensen et al. Science 2009). Despite many studies, it
is still unclear whether BRAF kinase signals only through MEK and CRAF, or
instead it also phosphorylates other substrates. Therefore, we aim to apply
a powerful systematic approach to this question. We have obtained a linear
phosphorylation motif for BRAF, which will enable us to computationally
predict potential substrates and model networks for this kinase. This will
potentially allow us to propose a future network medicine strategy for
melanoma and pave the way for similar studies in other cancers/diseases.
The project involves an international collaboration with Prof Neal Rosen’s
lab at the MSKCC (New York, USA) and Prof Ruedi Aebersold’s lab at the ETH
(Zürich, Switzerland), and is an integral part of the newly established
integrative network biology initiative (INBi) at DTU.

*Qualifications
*Candidates must hold a PhD degree (or equivalent) in molecular biology,
biochemistry, cell biology or a relevant field, and have experience of
mammalian tissue culture, protein biochemistry and signal transduction.
Experience in RNAi screening and cancer/tumour biology is a distinct
advantage. Experience with biological mass spectrometry (nLC-ESI-MS),
quantitative proteomics or phospho-proteomics and bioinformatics is
advantageous.

The post-holder must be keen to evaluate and analyse data of heterogeneous
types and apply computational biology and bioinformatics (including
statistics, machine learning and sequence analysis) to reach a deeper
understanding of data at hand. We are seeking highly motivated, bright
researchers and our lab is a dynamic, highly productive and stimulating
environment, where we provide world-class multi-disciplinary training.

*DTU offers
*DTU offers an interesting and challenging job in an international
environment focusing on education, research, public-sector consultancy and
innovation, which contribute to enhancing the economy and improving social
welfare. We strive for academic excellence, collegial respect and freedom
tempered by responsibility. DTU is a leading technical university in
northern Europe and benchmarks with the best universities in the world. We
will offer an attractive salary and the opportunity to take part in a
frontier cancer combating research program. Foreign nationals will be able
to enter Denmark on a very low tax rate.

*Salary and terms of employment
*The appointment will be based on the collective agreement with the
Confederation of Professional Associations. The allowance will be agreed
with the relevant union.

The period of employment is 3 years with possibility of extension.

*Application procedure
*We must have your online application by *5 March 2012*. To apply, please
open the link "apply for this job online" and fill in the application form
and attach your application, CV and diploma. The material that should be
given consideration in the assessment must be attached.

Applications should be submitted in English.

Applications and enclosures received after the deadline will not be
considered.

All interested candidates irrespective of age, gender, race, disability,
religion or ethnic background are encouraged to apply.

*Further information
*Further information may be obtained from Dr Rune Linding, tel: +45 2365
1941 orlinding at cbs.dtu.dk.

You can read more about the Center for Biological Sequence Analysis on
http://www.cbs.dtu.dkand about Rune Linding’s Research Group at
http://www.lindinglab.org.

-- 

Rune Linding - Research Group Leader, Guest Professor, PhD, Cand.Scient.

Cellular Signal Integration Group (C-SIG) - http://www.lindinglab.org

Center for Biological Sequence Analysis (CBS) - http://www.cbs.dtu.dk

Department of Systems Biology - Technical University of Denmark (DTU)

Building 301, DK-2800 Lyngby, DENMARK - Phone: +45 2365 1941


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<http://www.networkbio.org>
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