[SocBiN] Postdoctoral Position in Bioinformatics at SciLifeLab Stockholm

[Erik Sonnhammer]

See https://ki.mynetworkglobal.com/en/what:job/jobID:30300/where:4/

Note: Last application date:09.Jan.2014


*Postdoctoral Scientist in Bioinformatics*
The position is within an interdisciplinary team in the project 
"DIfferential Response by INtra Tumour Heterogeneity (DIRINTH)" headed 
by Thomas Helleday, Joakim Lundeberg, and Erik Sonnhammer at Science for 
Life Laboratory in Stockholm, Sweden. This project recently received 
funding for five years from AstraZeneca, and aims at mapping gene 
expression differences within solid tumors at the single cell level.

The project will generate a gene expression profile for each cell in a 
matrix of a tissue section, where the matrix contains up to 135000 
cells. Analysis of this data needs to be automated, and a bioinformatics 
groups is being established to build infrastructure to store and analyse 
the data. This position is mostly focussed on analysing the expression 
profiles to identify activated and deactivated pathways in a given cell 
type. To this end, novel statistical methods will be used, such as 
Network Crosstalk Enrichment Analysis (NCEA), in combination with 
traditional gene enrichment analysis (GEA). These will be combined with 
network module clustering using the MGclus method.

Specific aims:

Develop a pathway annotation pipeline for gene expression data based on 
NCEA, GEA, and MGclus.

Integrate the pathway annotation pipeline into the workflow of ST analysis.

Apply the pathway annotation pipeline to ST data, to be able to 
functionally characterize activated and deactivated pathways in 
different cell types.

Build a knowledge database for storing and mining ST data, pathway 
annotations, and external annotations, using standardized interfaces to 
analysis algorithms and methods.


*Entry requirements
*

The successful candidate should have a Ph.D. in bioinformatics or 
related field, and detailed knowledge of molecular biology. Familiarity 
with high throughput data analysis techniques is essential, as well as a 
high level of motivation. Computer programming skills and knowledge of 
biological database systems are important merits.

A person is eligible for a position as postdoctoral research fellow if 
he or she has obtained a PhD no more than seven years before the last 
date of employment as postdoc.

*Application process
*An employment application must contain the following documents in 
English or Swedish:

 1. A complete curriculum vitae, including date of the thesis defence,
    title of the thesis, previous academic positions, academic title,
    current position, academic distinctions, and committee work
 2. A complete list of publications
 3. A summary of current work (no more than one page)
 4. Verifications for crediting of illness, military service, work for
    labour unions or student organisations, parental leave or similar
    circumstances
 5. Verification from the thesis defence committee or the equivalent
    (only if the thesis defence is scheduled within three months after
    the application deadline)

The application is to be submitted on the NetRecruiter system, see See 
https://ki.mynetworkglobal.com/en/what:job/jobID:30300/where:4/

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