[SocBiN] PhD scholarships in computational genomics and transcriptional regulatory variation

[Robin Andersson]

Dear all,

We are looking to recruit up to two highly motivated and talented PhD students to join our group working on computational biology with a strong focus on enhancers and transcriptional regulation. The successful candidates are expected to start during spring 2017. Please see link below for more information and to apply online (application deadline: January 20, 2017).
http://employment.ku.dk/phd/?show=878622

Context
The lab of Robin Andersson focuses on genomics and computational/statistical modeling of transcriptional regulation based on large-scale sequencing data, including experimental data generated from within the lab. We aim to characterize and better understand the architectures and complexities of transcriptional regulation and gain insights into the mechanisms of regulation. We further focus on the fundamental properties of enhancers and promoters as well as the biogenesis and characteristics of enhancer RNAs. For more information, see http://anderssonlab.org.

Projects
The correct function of regulatory elements and their interplay are essential for the precisely coordinated transcriptional activities within a cell. Disrupted regulatory activities may therefore have detrimental effects leading to disease. However, most variants have no or an only weakly associated trait and, in general, the impact of genetic variants on regulation is not well understood. Therefore, using our established transcription-based method to assess activities of regulatory elements and the associations between them, we aim to systematically characterize human regulatory variation and its consequences. We further aim to infer models describing the function of a regulatory element and its importance, and thus the impact on regulation upon disruption.

The successful candidates are expected to work on projects related, but not limited, to 1) computational modeling of enhancer regulation and genome-wide mapping of enhancer architectures; and 2) assessment of the extent and impact of individual variation and genetic variants in regulatory architectures in order to understand their importance, stochasticity and robustness.

Best regards,
Robin Andersson

--
Robin Andersson, PhD
Assistant professor, group leader

The Bioinformatics Centre
Department of Biology
University of Copenhagen
Ole Maaloes Vej 5
DK-2200 Copenhagen N, Denmark

http://anderssonlab.org
Twitter: @robin_andersson
Skype: andersson.robin

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