[SocBiN] Two post-doc fellowships available

[Lionel Guy]

I have two post-doc fellowships available for two exciting projects: 

1. Evolvability of antibiotic resistance genes, collaboration with Diarmaid Hughes. 
2. Evolution of host-adaptation in the intracellular bacteria Legionellales. 

Deadline for applications February 18th, 2018. 
See full description below or on my website (http://www.imbim.uu.se/Research/Microbiology-immunology/guy-lionel/).

Best regards,

Lionel 

======= 1 =======
EVOLVABILITY OF ANTIBIOTIC RESISTANCE GENES, POST-DOC
Lionel Guy and Diarmaid Hughes are looking for a post-doctoral fellow with, ideally, experience of both bacterial genetics and molecular evolution to tackle a collaborative project on the evolvability of ancestral antibiotics resistance genes.

PROJECT
The mains goals are (i) to better understand how different antibiotic resistance genes evolved before the clinical use of antibiotics, and to assess (ii) their evolutionary potential and (iii) the predictability of the mutations providing antibiotic resistance. We will focus on four classes of genes providing resistance to four classes of antibiotics: beta-lactams, aminoglycosides, tetracycline and the last-resort antibiotic colistin.
First, the successful candidate will reconstruct the evolutionary history of each class of genes, trying to infer what they are derived from. Second, they will evaluate the resistance potential of ancestors, by reconstructing them, cloning them into E. coli MG1655 and assessing their minimal inhibitory concentrations (MIC). Third, the reconstructed ancestors will be evolved in sub-MIC conditions, to examine evolutionary paths and time necessary to reach present-day MICs.
By comparing the mutations obtained in experimental evolution to the ones found in actual modern sequences we’ll be watching how “replaying the tape of life” mimics the actual evolutionary pressures experienced by sequences in vivo, and may predict the potential emergence of antibiotics resistance in clinical settings.

FORM
Two-years post-doctoral fellowship (SEK 276 000, circa USD 32 400, per annum), free of tax. Fellowship rules exclude candidates with a PhD from the host institution (Uppsala University). The candidate has to be approved by the funder.
Starting date: to be discussed

BASIC SKILLS AND QUALIFICATIONS
- A PhD in molecular evolutionary biology, microbial genetics or a related topic.
- Experience with microbiology and bacterial genetics.
- Experience of bioinformatics, ability to run basic molecular evolution software.
- A documented experience of team work and collaborative projects.

DESIRED QUALIFICATIONS
- Extended experience of molecular evolution tools.
- Programming experience.
- Skills in molecular genetic tools in E. coli and Salmonella.

APPLICATIONS
To be sent by email to lionel.guy at imbim.uu.se, latest on February 18th, 2018. Applications (in one single document) should include:
- Letter of motivation.
- Resume.
- Publication list.
- Names and contact information of two references or two letters of reference.

HOST INSTITUTION
The project is a collaboration between the research groups of Lionel Guy and Diarmaid Hughes, Department of Medical Biochemistry Microbiology, Uppsala University. The host department is a very strong and stimulating research environment, counting over 250 researchers in over 30 groups, and is conducting world-leading research in antibiotic resistance.
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6.5 billion.

CONTACT
Lionel Guy, M: lionel.guy at imbim.uu.se, P: +46 18 471 42 46, W: http://www.imbim.uu.se/Research/Microbiology-immunology/guy-lionel/

======= 2 =======
POSTDOCTORAL FELLOW IN EVOLUTIONARY MICROBIOLOGY, BIOINFORMATICS
We are recruiting a new postdoctoral fellow to Lionel Guy’s research group at Uppsala University.

PROJECT
Our group is studying the evolution of host-adaptation in bacteria. We are currently focusing on the Legionellales order, which contains representatives at several stages of host adaptation. We are gathering a number of novel genomes through extended sampling, metagenomics and data mining. The goal of this project is to extend the current dataset, analyze it, to shed light on the evolution of Legionellales in particular, and on the evolutionary transitions in host adaptation in general.

FORM
One-year post-doctoral fellowship (SEK 288 000, circa USD 34 000, per annum); extension for a second year possible. Candidates who are employees of Uppsala University, or have been in the two years before the start of the fellowship, are not eligible.
Starting date: to be discussed.

BASIC SKILLS AND QUALIFICATIONS
- A PhD in evolutionary biology, molecular evolution, microbiology or related topic.
- Experience with high-throughput sequencing data, metagenomics, comparative genomics, and molecular evolution tools.
- A documented experience of team work and collaborative projects.

DESIRED QUALIFICATIONS
- Programming experience.

APPLICATIONS
To be sent by email to lionel.guy at imbim.uu.se, latest on January 18th, 2018. Applications (in one single document) should include:
- Letter of motivation.
- Resume.
- Publication list.
- Names and contact information of two references or two letters of reference.

HOST INSTITUTION
The group is located at the Department of Medical Biochemistry Microbiology, Uppsala University. The host department is a very strong and stimulating research environment, counting over 250 researchers in over 30 groups, and is conducting world-leading research in antibiotic resistance.
Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6.5 billion.

CONTACT
Lionel Guy, M: lionel.guy at imbim.uu.se, P: +46 18 471 42 46, W: http://www.imbim.uu.se/Research/Microbiology-immunology/guy-lionel/

--
Lionel Guy, PhD
Assistant Professor (forskarassistent), Docent in Evolutionary Microbiology
Department for Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
lionel.guy at imbim.uu.se