[SocBiN] Fwd: [3d-bioinfo-steering-committee] Webinar Today Activity 2

[Arne Elofsson]

---------- Forwarded message ---------
From: R. Gonzalo Parra via 3d-bioinfo-steering-committee <
3d-bioinfo-steering-committee at elixir-europe.org>
Date: Tue, 8 Apr 2025, 12:00
Subject: [3d-bioinfo-steering-committee] Webinar Today Activity 2
To: Nathalie Reuter via 3d-bioinfo-steering-committee <
3d-bioinfo-steering-committee at elixir-europe.org>


Dear all,

We will have a new webinar today from Activity 2!

Prof. Qian Cong
*Computing the Human interactome*
Protein-protein interactions (PPI) are essential for biological function.
Recent advances in coevolutionary analysis and Deep Learning (DL) based
protein structure prediction have enabled comprehensive PPI identification
in bacterial and yeast proteomes, but these approaches have limited success
to date for the more complex human proteome. Here, we overcome this
challenge by 1) enhancing the coevolutionary signals with 7-fold deeper
multiple sequence alignments harvested from 30 petabytes of unassembled
genomic data, and 2) developing a new DL network trained on augmented
datasets of domain-domain interactions from 200 million predicted protein
structures. These advancements allow us to systematically screen through
200 million human protein pairs and predict 18,316 PPIs with an expected
precision of 90%, among which 5,578 are novel predictions. 3D models of
these predicted PPIs nearly triple the number of human PPIs with accurate
structural information, providing numerous insights into protein function
and mechanisms of human diseases.

Here is the zoom link:
https://stockholmuniversity.zoom.us/my/arneelof/

Please join if you can and spread the word in your social circles.

Best,

Gonzalo
-----
Dr. R. Gonzalo Parra
Established Researcher (R3)
Life Sciences Department
Barcelona Supercomputing Center
Barcelona, Spain
https://www.bsc.es/discover-bsc/organisation/scientific-structure/computational-biology
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