[Socbin] PhD position for European students

Arne Elofsson arne at bioinfo.se
Tue Apr 8 22:10:37 CEST 2008


Dead friends

We (Gunnar von Heijne) and I have two PhD openings specifically for
European, but non-Swedish students. So if you have some excellent
experimental or bioinformatical students, please ask them to look at
http://bioinfo.se/positions.shtml for instructions on how to apply.
See below for two possible projects.


yours

Arne



Project title: Membrane protein interactions: modelling and
experiment, Ref-No: DBB-08-GvH-01
Project leader: Gunnar von Heijne (gunnar at dbb.su.se)

Most integral membrane proteins are part of larger complexes. However,
the interactions that drive protein-protein interactions in membranes
are poorly understood. In this project, theoretical and experimental
techniques (cloning, site-directed mutagenesis) will be combined to
analyze and possibly predict interactions between membrane proteins,
mainly using model proteins expressed in E. coli. Wet-lab experience
of molecular biology work is required. The position is funded by a EU
grant and can only be applied for by students who are residents in a
EU (associated) country other than Sweden.
PhD position in "Studies of folding, insertion and interactions of
membrane helices.", Ref No: DBB-AE-2008-02
So far the insertion of helices by the translocon has mainly been
studied by artificially designed single helices. However, as noticed
many helices do not seem to be hydrophobic enough to be inserted
without the help of neighboring helices. Therefore, the insertion of
such marginally hydrophobic helices in vivo and in vitro is important
to provide insight into how membrane helices are inserted. In this
project, theoretical studies of membrane proteins will be combined
with experimental techniques (cloning, site-directed mutagenesis) to
analyze the insertion, folding and interaction of TM-helices. We seek
outstanding PhD candidates with knowledge of bioinformatics and/or
wet-lab molecular biology techniques. The position is funded by a EU
grant and can only be applied for by students who are residents in a
EU (associated) country other than Sweden.

yours

Arne

-- 
---------------------------------------------------------
Prof. Arne Elofsson Dep of Biochemistry and Biophysics
 Tel:+46-8-16 4672 Stockholm University
 Fax:+46-8-15 3679 10691 Stockholm, Sweden
 Directions: see http://bioinfo.se/misc/directions.html
 Net: arne at bioinfo.se http://bioinfo.se/


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