[SocBiN] Position at EBI+SciLifeLab

[Arne Elofsson]

The three-dimensional (3D) structure dictates its function and can
facilitate mechanistic understanding of biological processes. The recent
advances in Artificial Intelligence (AI)-based methods, such as AlphaFold
and RoseTTaFold, provide high-quality structure models for
biomacromolecules (proteins and nucleic acids) and their complexes small
molecule ligands and have transformed basic and translational life science
research.  The predicted models offer deeper insights into the functional
sites and interaction surfaces underpinning their biological roles.

Elofsson and Velankar teams are interested in exploring some of the
computational challenges in employing AI-based methods for predicting large
biomacromolecular complexes and generate a set of high-quality structure
models. This will be achieved by refining the strategies for predicting
larger biomacromolecular complexes (more than two subunits) and cataloguing
the biomacromolecular interactions in the human proteome. To make the
structural data accessible and valuable in driving life science research,
we are interested in exploiting knowledge graphs (KG) techniques to enrich
the data with structural and functional annotations. The KG will allow
reasoning over the annotations and knowledge transfer across related
proteins by providing a structured representation of known annotations
through nodes and edges.

The method developed within this ARISE2 project will be tested with data
and biological questions arising at the EMBL and SciLifeLab cryo-EM and
integrative structural biology facilities and will be useful for a large
community of researchers in structural biology.


ARISE2 (https://www.embl.org/training/arise2/)

ARISE2 targets technology and method development experts with STEM
backgrounds interested in using their expertise to advance research in the
life sciences.

To address urgent challenges to human and planetary health, new
technologies and services are needed in the Life Sciences. ARISE2 is
designed to meet this need by training fellows in the development of
technologies and methods for the improvement of scientific services while
also preparing them for careers in research infrastructures (RI) to make
these advances available to the scientific community, accelerating
progress.

ARISE2 is an MSCA-funded postdoctoral fellowship programme offering
talented STEM (science, technology, engineering and mathematics) fellows
from around the world the unique opportunity to work on the development
and/or improvement of technologies for Life Science Research while
developing the expertise needed for a career in research infrastructures
making them sought after experts both in academia and industry.
Location of this position

This position is primarily located at EMBL-EBI, Cambridge, UK, but
extensive time will also be allocated to working with the researchers at
the Science for Life Laboratory, Stockholm, Sweden. The fellow will visit
the Science for Life Laboratory, Stockholm, Sweden. The position is for
three years.
Application

Please send a two-page CV and a two-page project proposal within the area
outlined above to Sameer Velankar <sameer at ebi.ac.uk> by Nov 5, 2024.  The
two-page proposal should cover the following areas -

   -

   Background, proposed project
   -

   Expected results & their impact
   -

   Service to be offered
   -

   Consideration of FAIR principals


This is a pre-proposal. In the second step, we will select one candidate by
November 12 at the latest, and together with the candidate, we will submit
a full proposal by the deadline for the ARISE2 call on November 25.
Contacts:

More information about the ARISE2 program can be found at
https://www.embl.org/training/arise2/


   -

   For this application
   -

      Marta Carroni <marta.carroni at scilifelab.se>
      -

      Sameer Velankar <sameer at ebi.ac.uk>
      -

      Arne Elofsson <arne at bioinfo.se>
      -

   For questions about  the ARISE2 program
   -

      arise2 at embl.org




Yours

Arne

-----------------------------------------
  Arne Elofsson                  Science for Life Laboratory
  Tel:+46-(0)70 695 1045   Stockholm University
  http://bioinfo.se/               Box 1031,
  Email: arne at bioinfo.se   17121 Solna, Sweden
  Twitter:   https://twitter.com/arneelof
  Zoom: https://stockholmuniversity.zoom.us/my/arneelof/
  Scholar: http://scholar.google.se/citations?user=s3OCM3AAAAAJ
  ORCID: 0000-0002-7115-9751
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