[SocBiN] Senior Applied Researcher - MSR AI for Science
Arne Elofsson
arne.elofsson at gmail.com
Wed Oct 29 08:57:56 CET 2025
From Frank Noe
see: aka.ms/bioemu-applied
Basicly we’re looking for a computational biologist / bioinformatician who
would enjoy running and automating BioEmu and other structure-based tools
and databases on very large scale and creating structure-based models of
dynamics of entire pathways or proteomes. The person should be quite
technical and have a good understanding of structural biology (tricky
combination).
The person will also co-lead a partnership with a drug discovery
collaborator who will bring in lots of experimental data to train the next
BioEmu version and be responsible for helping to make the connection
between experimentalists and ML researchers.
Do you know anyone who might be a fit and is available? They need to have a
PhD (or expect it soon), but they could be significantly more senior.
Senior Applied Researcher - MSR AI for Science
Multiple Locations, Germany
+ 1 more location
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Date posted
Oct 01, 2025
Job number
1885746
Work site
3 days / week in-office
Travel
0-25 %
Role type
Individual Contributor
Profession
Research, Applied, & Data Sciences
Discipline
Research Sciences
Employment type
Full-Time
------------------------------
Overview
At Microsoft Research AI for Science
<https://www.microsoft.com/en-us/research/lab/microsoft-research-ai-for-science>,
we believe machine learning and artificial intelligence has the potential
to transform scientific modelling and discovery crucial for solving the
most pressing problems facing society including sustainable materials and
discovery of new drugs.
We seek a highly motivated Senior Applied Researcher to join our
Biomolecular Emulator (BioEmu) team. The BioEmu project aims to model the
dynamics and function of proteins - how they change shape, bind to each
other, and bind small molecules. This approach will help us to understand
biological function and dysfunction on a structural level and lead to more
effective and targeted drug discovery. Our BioEmu-1 model was published in
Science <https://www.science.org/doi/10.1126/science.adv9817> (see our blog
post
<https://www.microsoft.com/en-us/research/blog/exploring-the-structural-changes-driving-protein-function-with-bioemu-1>
for links to our open-source software and other resources and this explainer
video <https://www.youtube.com/watch?v=LStKhWcL0VE>).
Qualifications
Required:
- PhD or equivalent research experience in Chemistry, Biophysics,
Physics, Computer Science, Bioinformatics or a related field.
- Demonstrated passion and proven excellence in computational molecular
biology, biophysics, or bioinformatics via impactful projects,
publications, or open‑source code.
- Experience with biomolecular modeling/bioinformatics (e.g., folding
systems, structural analysis, MD simulation, structure/genome databases).
- Excellent technical communication for interdisciplinary work.
- Comfortable with real‑world data that lack
structure/cleanliness/completeness.
- Proficiency in Python and data analysis packages (NumPy, SciPy,
Pandas).
Preferred:
- Experience with deep learning methods and software packages (PyTorch,
JAX, Tensorflow).
- Experience with structural biology or molecular biology
data/techniques (e.g., cryo‑EM, binding assays, spectroscopy, expression,
sequencing).
- Background or advanced training in structural biology; familiarity
with structure prediction and/or MD work-flows.
#Research #AI for Science
In line with our Flexible Work approach, for roles at Microsoft Germany, we
recommend spending at least two days per week in the office or at the
customer site. The actual number of days to work from the office or at the
customer will be defined in agreement between the employee and their
manager.
Responsibilities
- Model biomolecular structure and dynamics at scale: Use BioEmu,
structure/sequence databases, and complementary tools to analyze proteins
and complexes.
- Innovate and improve analysis technologies: Develop and implement
scalable technologies to analyze and quantify conformational transitions,
structural flexibility, and changes in complex formation for many
biomolecular complexes.
- Generate biological hypotheses and insights: Integrate biomolecular
structure and dynamics data to generate experimentally-testable predictions
and biological insights.
- Collaborate with experimentalists: collaborate with wetlab scientists
to test computational predictions. Learn to read and interpret their data
and work together to challenge and improve hypothesis of biomolecular
function.
- Support drug‑targeting strategies: Partner with leading drug discovery
experts to identify targets and propose mechanisms of action.
- Operationalize at scale: Build robust Python pipelines; automate
large‑scale inference and analysis jobs on Azure with reproducible
work-flows.
- Partner across disciplines: communicate clearly with ML researchers
and experimental/computational biologists; present results and influence
project direction.
- Work autonomously and as a team player, regularly reporting insights,
risks, and next steps.
- Aim for impact: translate findings into artifacts others can use
(code, datasets, internal reports, and when appropriate - papers).
------------------------------
Benefits/perks listed below may vary depending on the nature of your
employment with Microsoft and the country where you work.
**Industry leading healthcare
**Educational resources
**Discounts on products and services
**Savings and investments
**Maternity and paternity leave
**Generous time away
**Giving programs
**Opportunities to network and connect
------------------------------
Microsoft is an equal opportunity employer. All qualified applicants will
receive consideration for employment without regard to age, ancestry,
citizenship, color, family or medical care leave, gender identity or
expression, genetic information, immigration status, marital status,
medical condition, national origin, physical or mental disability,
political affiliation, protected veteran or military status, race,
ethnicity, religion, sex (including pregnancy), sexual orientation, or any
other characteristic protected by applicable local laws, regulations and
ordinances. If you need assistance and/or a reasonable accommodation due to
a disability during the application process, read more about requesting
accommodations
<https://careers.microsoft.com/v2/global/en/accessibility.html>.
Yours
Arne
-----------------------------------------
Arne Elofsson Science for Life Laboratory
Tel:+46-(0)70 695 1045 Stockholm University
http://bioinfo.se/ Box 1031,
Email: arne at bioinfo.se 17121 Solna, Sweden
Bluesky: @bioinfo.se
Twitter/X: @arneelof
Mastodon: @arneelof at fediscience.org
Zoom: https://stockholmuniversity.zoom.us/my/arneelof/
Scholar: http://scholar.google.se/citations?user=s3OCM3AAAAAJ
ORCID: 0000-0002-7115-9751 <https://orcid.org/0000-0002-7115-9751>
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