[SocBiN] Doktorand / PhD position: Bioinformatics and Mechanistic Modelling for Precision Medicine, Örebro University, Schweden

[Dirk Repsilber]

*Doktorand / PhD position: Bioinformatics and Mechanistic Modelling for 
Precision Medicine, Örebro University, Schweden*

Deadline for application:
2025-10-31

Website for application:
https://www.oru.se/english/career/available-positions/job/?jid=20250281

Join the X-HiDE/ROSETTA research collaboration to develop and evaluate 
hybrid modelling approaches that integrate mechanistic models of 
inflammation and diet-inflammation interactions with statistical models 
using large-scale molecular data. The project aims to improve disease 
phenotype classification and deepen mechanistic understanding across 
inflammation driven complex diseases, and dietary response types. This 
interdisciplinary work connects bioinformatics and systems biology 
approaches with precision medicine, and responsive nutrition, and is 
integrated with international and industry partners.

The PhD position is located at the School of Medical Sciences (MV), 
Örebro University, a modern and expanding university with approximately 
1,600 employees and 17,000 students. MV also hosts the university's 
medical program and drives several research centers primarily focused on 
inflammation, metabolism, and nutrition.

X-HiDE, Exploring Inflammation in Health and Disease, is a strategic 
research initiative at Örebro University. Using a systems-analytical 
approach, and employing different kinds of modelling approaches, X-HiDE 
explores the mechanisms of inflammation across different diseases to 
investigate shared and distinct inflammatory phenotypes. The Research 
Center Responsive Nutrition, ROSETTA at oru, is a multidisciplinary 
research initiative focused on the complex interactions between diet and 
human gut, metabolic and mental health. By combining advanced molecular 
analysis with clinical studies, ROSETTA aims to identify how and when 
individual differences affect dietary health effects. The project 
explores how food can be used as a tool to prevent or manage 
inflammation-mediated disorders, such as IBS, IBD and various mental 
disorders and supports the development of personalized nutrition 
strategies. Both environments are part of Örebro University's new Center 
for Food and Health and bring together interdisciplinary expertise and 
collaborate closely together and with academic, clinical, and industrial 
partners to advance precision medicine and translational research. The 
Bioinformatics group at Örebro University is an integrated part of both 
centres, with focus on new methods for analysing and modelling molecular 
data, cellular mechanisms and clinical phenotypes, based on both 
statistics/machine learning and computational mechanistic modelling. The 
group specializes in analysing complex OMICs datasets (e.g., 
transcriptomics, proteomics, microbiota) to uncover biosignatures and 
causal mechanisms in health and disease. Their work connects systems 
biology, statistical learning, and translational medicine, with 
applications in inflammation research, gut-brain interactions, and 
personalized nutrition.

Supervision: You will be supervised by Dirk Repsilber (prof 
bioinformatics, principal supervisor) and a team of assistant 
supervisors from both research platforms, X-HiDE and Rosetta.

The doctoral programme consists of courses and an independent research 
project that you will present in a doctoral thesis. The programme 
concludes with a doctoral degree and comprises 240 credits, which 
corresponds to four years of full-time study.

Our ambition is to enable stimulating and purposeful doctoral studies 
for you, throughout the programme, until you have obtained your doctoral 
degree. A thorough introduction will therefore get you off to a good 
start and provide a solid foundation on which you can build your 
studies. As a doctoral student at Örebro University, you will be offered 
a specially tailored seminar series, covering matters ranging from 
doctoral programme rules and careers to support during the study period 
and networking. You will be offered to join the national Graduate School 
MedBioInfo, for advanced courses in Bioinformatics and networking on a 
national level.

The place on the programme is linked to a full-time doctoral studentship 
for the duration of the study programme, which corresponds to four years 
of full-time study. More information on doctoral studentships, part-time 
studies and part-time doctoral studentships can be found in the 
Regulations Handbook. The initial salary for a doctoral studentship is 
SEK 31,300 a month.

For more information about the programme and the doctoral studentship, 
contact Professor Dirk Repsilber (dirk.repsilber at oru.se).

-- 
______________________________________________________

Dirk Repsilber

Bioinformatics
School of Medical Sciences (MV)
University of Örebro
S - 701 82  Örebro
Sweden
+46 73 270 7633
https://www.oru.se/personal/dirk_repsilber
______________________________________________________
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